Loyola University Parkinson School of Health Sciences and Public Health, Maywood, Illinois, USA.
Department of Medical Laboratory Science, Marquette University, Milwaukee, Wisconsin, USA.
Clin Med Res. 2024 Mar;22(1):13-18. doi: 10.3121/cmr.2024.1871.
remains a difficult sexually-transmitted infection (STI) to manage due to its potential for antimicrobial resistance and post-infection sequelae. University students are especially vulnerable, as this demographic has the highest rate of STI in the United States. As a result, investigating prevalence rates and therapeutic outcomes in this population is essential to minimize future impact of The purpose of this study was to investigate a university student population for distribution and treatment outcome. Retrospective chart-review of university health clinic attendees, augmented by laboratory detection of following therapeutic intervention. A total of 1617 student encounters at a midwestern United States university health clinic over a 28-month interval from November 2017 through February 2020 were analyzed for and positivity rates and prevalence. Detection of these sexually-transmitted pathogens occurred by commercial RNA amplification testing. Chart review was focused on participant outcomes following initial detection and therapeutic intervention. positivity and prevalence rates were 7.05% and 9.00%, respectively, while analogous rates for were 7.05% and 6.51%, respectively. An average of 1.83 positive results was generated from participants infected with at any time, with an average of 1.17 positive results for ( < 0.0002). For students treated with azithromycin, 30.3% generated a negative result upon follow-up, with 1g daily and 2-day 500mg dosing regimens demonstrating less efficacy than a 4-day 250mg regimen or moxifloxacin. Data indicate a need for molecular macrolide resistance determination from primary specimens in the university setting.
remains a difficult sexually-transmitted infection (STI) to manage due to its potential for antimicrobial resistance and post-infection sequelae. University students are especially vulnerable, as this demographic has the highest rate of STI in the United States. As a result, investigating prevalence rates and therapeutic outcomes in this population is essential to minimize future impact of The purpose of this study was to investigate a university student population for distribution and treatment outcome. Retrospective chart-review of university health clinic attendees, augmented by laboratory detection of following therapeutic intervention. A total of 1617 student encounters at a midwestern United States university health clinic over a 28-month interval from November 2017 through February 2020 were analyzed for and positivity rates and prevalence. Detection of these sexually-transmitted pathogens occurred by commercial RNA amplification testing. Chart review was focused on participant outcomes following initial detection and therapeutic intervention. positivity and prevalence rates were 7.05% and 9.00%, respectively, while analogous rates for were 7.05% and 6.51%, respectively. An average of 1.83 positive results was generated from participants infected with at any time, with an average of 1.17 positive results for ( < 0.0002). For students treated with azithromycin, 30.3% generated a negative result upon follow-up, with 1g daily and 2-day 500mg dosing regimens demonstrating less efficacy than a 4-day 250mg regimen or moxifloxacin. Data indicate a need for molecular macrolide resistance determination from primary specimens in the university setting.
仍然是一种难以治疗的性传播感染（STI），因为它具有抗菌药物耐药性和感染后后遗症的潜力。大学生尤其容易受到感染，因为这一年龄段的性传播感染率在美国是最高的。因此，调查这一人群的流行率和治疗结果对于最大限度地减少未来的影响至关重要。本研究的目的是调查大学生群体中 的分布和治疗结果。对美国中西部一所大学健康诊所的就诊者进行回顾性图表审查，并在治疗干预后通过实验室检测 。对 2017 年 11 月至 2020 年 2 月期间的 28 个月内，在该大学健康诊所就诊的 1617 名学生进行了 和 阳性率和患病率分析。通过商业 RNA 扩增检测来检测这些性传播病原体。图表审查的重点是参与者在初次检测和治疗干预后的结果。 和 的阳性率分别为 7.05%和 9.00%，而 的类似比率分别为 7.05%和 6.51%。任何时候感染 的参与者平均产生 1.83 个阳性结果，感染 的参与者平均产生 1.17 个阳性结果（<0.0002）。接受阿奇霉素治疗的学生中，30.3%在随访时产生了 的阴性结果，1g 每日和 2 天 500mg 剂量方案的疗效不如 4 天 250mg 方案或莫西沙星。数据表明，在大学环境中，需要从原始标本中进行分子 大环内酯类药物耐药性测定。
