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蒲公英()和牛蒡()根提取物的抗糖尿病特性。

Antidiabetic Properties of the Root Extracts of Dandelion () and Burdock ().

作者信息

Zolotova Daria, Teterovska Renāte, Bandere Dace, Lauberte Liga, Niedra Santa

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rīga Stradiņš University, LV-1007 Riga, Latvia.

Department of Pharmaceuticals, Red Cross Medical College, Rīga Stradiņš University, LV-1007 Riga, Latvia.

出版信息

Plants (Basel). 2024 Apr 3;13(7):1021. doi: 10.3390/plants13071021.

Abstract

Several preclinical studies suggest the potential of edible plants in controlling blood sugar levels and stabilizing diet. The goals of the study were to examine, analyze, and describe whether there are chemical compounds in dandelion and burdock roots that could have antidiabetic properties. The 70% ethyl alcohol and lyophilizate extracts (AE and LE, respectively), were used, and analyses were carried out on their total polysaccharide (TP), total phenolic content (TPC), tannin, and inulin. The antioxidant activity of extracts was determined using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, and hypoglycemic properties were based on α-amylase activity. Liquid chromatography-mass spectrometry was used for the tentative identification of the chemical components. Qualitative techniques confirmed the presence of inulin in both roots. Analysis of TPC, tannin content, DPPH assay, and α-amylase activity revealed higher values for burdock compared to dandelion. However, dandelion exhibited higher TP content. Burdock contained a small amount of tannin, whereas the tannin content in dandelion was insignificant. All LE consistently exhibited higher values in all analyses and assays for all roots compared to AE. Despite burdock root showing overall better results, it is uncertain whether these plants can be recommended as antidiabetic agents without in vivo studies.

摘要

多项临床前研究表明可食用植物在控制血糖水平和稳定饮食方面具有潜力。该研究的目的是检测、分析和描述蒲公英根和牛蒡根中是否存在具有抗糖尿病特性的化合物。使用了70%乙醇提取物和冻干提取物(分别为AE和LE),并对其总多糖(TP)、总酚含量(TPC)、单宁和菊粉进行了分析。提取物的抗氧化活性通过DPPH(2,2-二苯基-1-苦基肼)测定法确定,而降血糖特性基于α-淀粉酶活性。液相色谱-质谱联用用于化学成分的初步鉴定。定性技术证实两种根中均存在菊粉。对TPC、单宁含量、DPPH测定和α-淀粉酶活性的分析表明,与蒲公英相比,牛蒡的各项值更高。然而,蒲公英的TP含量更高。牛蒡含有少量单宁,而蒲公英中的单宁含量微不足道。与AE相比,所有根的所有LE在所有分析和测定中始终表现出更高的值。尽管牛蒡根总体上显示出更好的结果,但在没有体内研究的情况下,尚不确定这些植物是否可作为抗糖尿病药物推荐。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0d1/11013470/ad2c0119b1c9/plants-13-01021-g001.jpg

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