Darbyshire P J, Smith J H, Oakhill A, Mott M G
Cancer. 1985 Oct 1;56(7):1584-9. doi: 10.1002/1097-0142(19851001)56:7<1584::aid-cncr2820560720>3.0.co;2-l.
The clinical and pathologic features of eight infants with monocytic leukemia are reviewed. The children were all aged 12 months or less at diagnosis and had a high incidence of extramedullary features, skin infiltration being particularly common. The diagnosis was established by conventional morphologic and cytochemical techniques. Using the French-American-British (FAB) classification, five infants had FAB 5a disease, and three had FAB 5b. The difficulties in making the diagnosis from extramedullary sites and the overlap that exists at this age between monocytic leukemia, true histiocytic lymphoma, and malignant histiocytosis are discussed. The treatments given to the group and their response are reviewed. Five of the patients received VP-16-213 and cyclophosphamide as primary induction chemotherapy, a combination that merits further evaluation in leukemia with monocytic features.
本文回顾了8例单核细胞白血病婴儿的临床和病理特征。这些儿童在诊断时均未满12个月，髓外表现发生率高，皮肤浸润尤为常见。诊断通过传统形态学和细胞化学技术确立。采用法国-美国-英国（FAB）分类法，5例婴儿为FAB 5a型疾病，3例为FAB 5b型。讨论了从髓外部位进行诊断的困难以及该年龄段单核细胞白血病、真性组织细胞淋巴瘤和恶性组织细胞增多症之间存在的重叠情况。回顾了该组患者接受的治疗及其反应。5例患者接受VP-16-213和环磷酰胺作为初始诱导化疗，这种联合方案值得在具有单核细胞特征的白血病中进一步评估。
