Stiller C A, Eatock E M
Department of Paediatrics, University of Oxford.
Arch Dis Child. 1994 Mar;70(3):219-23. doi: 10.1136/adc.70.3.219.
Survival rates were studied among 1258 children with acute non-lymphocytic leukaemia diagnosed in 1971-88 and included in the population based National Registry of Childhood Tumours. Of the total, 147 (12%) died without receiving treatment. Among the remaining treated children, actuarial five year survival rates were 6% in 1971-4, 15% in 1975-9, 23% in 1980-3, and 40% in 1984-8. Infants aged less than 1 year had a significantly worse prognosis and there was a significant trend towards lower survival rates with increasing white cell count. No independent significant effects on survival were found with sex, French-American-British (FAB) subtype, or the presence or absence of Down's syndrome. Children entered in national trials had a higher survival rate than those who were not entered, and children treated at teaching hospitals had a higher survival rate than those who were treated elsewhere. Among the 535 (43%) children who survived at least one year from diagnosis no factor studied had a significant effect on survival, emphasising the importance of achieving first remission as a determinant of long term survival.
对1971年至1988年确诊的1258例急性非淋巴细胞白血病儿童的生存率进行了研究，这些儿童均被纳入基于人群的国家儿童肿瘤登记处。其中，147例（12%）未接受治疗即死亡。在其余接受治疗的儿童中，1971年至1974年的精算五年生存率为6%，1975年至1979年为15%，1980年至1983年为23%，1984年至1988年为40%。年龄小于1岁的婴儿预后明显较差，并且随着白细胞计数的增加，生存率有显著下降的趋势。未发现性别、法美英（FAB）亚型或唐氏综合征的有无对生存率有独立的显著影响。参加全国试验的儿童生存率高于未参加的儿童，在教学医院接受治疗的儿童生存率高于在其他地方接受治疗的儿童。在535例（43%）自诊断后至少存活一年的儿童中，所研究的因素均未对生存率产生显著影响，这强调了实现首次缓解作为长期生存决定因素的重要性。
