Comparative Genomic Analysis of : Insights into Its Genetic Diversity, Metabolic Function, and Antibiotic Resistance.

: is widely utilized in the fermentation industry and offers potential health benefits. However, large-scale comparative genomic analyses aimed at exploring its metabolic functions and conducting safety assessments are still lacking. : In this study, we performed a comparative genomic analysis of 324 strains sourced from various origins and geographical locations. : The results revealed that possesses a total of 2403 core genes, of which 12.3% have an unknown function. The phylogenetic analysis revealed a mixed distribution from various origins, suggesting complex transmission pathways. The metabolic analysis demonstrated that strains can produce several beneficial metabolites, including lysine, acetate, and riboflavin. Furthermore, is highly capable of degrading various carbohydrates and proteins, increasing its adaptability. Further, we profiled the antimicrobial peptides (AMPs) in the genomes of . We identified a widely distributed AMP and its variants, presenting in a total of 280 genomes. In our biosafety assessment of , we identified several antibiotic resistance genes, such as , , and , which may have potential for horizontal gene transfer within the family. : This study provides genomic insights into the genetic diversity, metabolic functions, antimicrobial properties, and biosafety of , underscoring its potential applications in biotechnology and environmental adaptation.