First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250000, Shandong, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, Shandong, China.
Inflamm Res. 2024 Jun;73(6):997-1018. doi: 10.1007/s00011-024-01879-4. Epub 2024 Apr 14.
ALI/ARDS is a syndrome of acute onset characterized by progressive hypoxemia and noncardiogenic pulmonary edema as the primary clinical manifestations. Necroptosis is a form of programmed cell necrosis that is precisely regulated by molecular signals. This process is characterized by organelle swelling and membrane rupture, is highly immunogenic, involves extensive crosstalk with various cellular stress mechanisms, and is significantly implicated in the onset and progression of ALI/ARDS.
The current body of literature on necroptosis and ALI/ARDS was thoroughly reviewed. Initially, an overview of the molecular mechanism of necroptosis was provided, followed by an examination of its interactions with apoptosis, pyroptosis, autophagy, ferroptosis, PANOptosis, and NETosis. Subsequently, the involvement of necroptosis in various stages of ALI/ARDS progression was delineated. Lastly, drugs targeting necroptosis, biomarkers, and current obstacles were presented.
Necroptosis plays an important role in the progression of ALI/ARDS. However, since ALI/ARDS is a clinical syndrome caused by a variety of mechanisms, we emphasize that while focusing on necroptosis, it may be more beneficial to treat ALI/ARDS by collaborating with other mechanisms.
ALI/ARDS 是一种以进行性低氧血症和非心源性肺水肿为主要临床表现的急性发作综合征。细胞坏死性凋亡是一种程序性细胞坏死形式，受到分子信号的精确调控。这一过程的特征是细胞器肿胀和膜破裂，具有高度的免疫原性，涉及与各种细胞应激机制的广泛串扰，并显著参与 ALI/ARDS 的发病和进展。
对细胞坏死性凋亡与 ALI/ARDS 的现有文献进行了全面综述。首先概述了细胞坏死性凋亡的分子机制，然后研究了其与细胞凋亡、细胞焦亡、自噬、铁死亡、全细胞凋亡和 NETosis 的相互作用。随后，阐述了细胞坏死性凋亡在 ALI/ARDS 进展的各个阶段的作用。最后介绍了针对细胞坏死性凋亡的药物、生物标志物和当前的障碍。
细胞坏死性凋亡在 ALI/ARDS 的进展中起重要作用。然而，由于 ALI/ARDS 是一种由多种机制引起的临床综合征，我们强调，在关注细胞坏死性凋亡的同时，通过与其他机制合作来治疗 ALI/ARDS 可能更为有益。
