Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, Central Tehran Branch, Tehran, Iran.
Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Neuropsychopharmacol Rep. 2024 Jun;44(2):300-307. doi: 10.1002/npr2.12437. Epub 2024 Apr 16.
Children with attention deficit hyperactivity disorder (ADHD) may benefit from probiotics and prebiotics, but the effects are unclear. To determine whether probiotics and prebiotics affect children with ADHD, a systematic review was conducted.
The present systematic review analyzed cohort studies and randomized controlled trials that examined whether prebiotics and probiotics are associated with ADHD. Seven randomized controlled trials and two cohort studies met our inclusion criteria.
Research on Lactobacillus rhamnosus GG (LGG) probiotic supplementation showed that children with ADHD had better emotional, physical, social, and school functioning, and a higher health-related quality of life compared to the placebo group. The studies also showed that Synbiotic 2000 reduces markers of intestinal and vascular inflammation in children with ADHD, in part through increasing SCFA levels.
The use of probiotics and prebiotics as adjuvants therapy in patients with ADHD is beneficial. Further studies with longer duration, including more participants and a variety of age groups, and using various evaluation techniques such as in vivo observation are required to examine the effects of prebiotics and probiotics on ADHD.
患有注意缺陷多动障碍（ADHD）的儿童可能受益于益生菌和益生元，但效果尚不清楚。为了确定益生菌和益生元是否会影响 ADHD 儿童，我们进行了系统评价。
本系统评价分析了队列研究和随机对照试验，以观察益生元和益生菌是否与 ADHD 相关。有 7 项随机对照试验和 2 项队列研究符合我们的纳入标准。
研究发现，补充鼠李糖乳杆菌 GG（LGG）益生菌可改善 ADHD 儿童的情绪、身体、社交和学校功能，以及更高的健康相关生活质量，与安慰剂组相比。这些研究还表明，Synbiotic 2000 通过增加短链脂肪酸（SCFA）水平，降低 ADHD 儿童的肠道和血管炎症标志物。
益生菌和益生元作为 ADHD 患者的辅助治疗是有益的。需要进行更多持续时间更长、包括更多参与者和各种年龄组的研究，并使用各种评估技术，如体内观察，以检查益生元和益生菌对 ADHD 的影响。
