Department of Pediatric Neurology, National Taiwan University Children's Hospital, Taipei 100, Taiwan.
Department of Pediatrics, Taipei City Hospital Heping Fuyou Branch, Taipei 100, Taiwan.
Nutrients. 2021 Oct 21;13(11):3698. doi: 10.3390/nu13113698.
Tourette syndrome results from a complex interaction between social-environmental factors, multiple genetic abnormalities, and neurotransmitter disturbances. This study is a double-blinded, randomized controlled trial using probiotics PS128 as an intervention to examine if probiotics improve symptoms of children with Tourette syndrome. This study enrolled children aged 5 to 18 years old who fulfilled DSM-V diagnostic criteria for Tourette syndrome. Patients were assessed before initiating the trial, at one month, and at two months after randomization. The primary outcome was evaluated by Yale Global Tic Severity Scale (YGTSS), and the secondary outcome studied the possible comorbidities in these children. The results revealed no significant difference in improvement in YGTSS between the control group and the PS128 group. As for secondary endpoints, an analysis of Conners' Continuous Performance Test (CPT) showed improvement in commission and detectability in the PS128 group. In conclusion, although probiotics may not have tic-reducing effects in children with Tourette syndrome, it may have benefits on comorbidities such as attention deficit and hyperactivity disorder (ADHD). Further studies are needed to clarify the effects of probiotics on the comorbidities of Tourette syndrome children.
妥瑞氏症是由社会环境因素、多种基因异常和神经递质紊乱等复杂因素相互作用引起的。本研究采用双盲、随机对照试验，使用 PS128 益生菌作为干预措施，以检验益生菌是否能改善妥瑞氏症儿童的症状。本研究纳入了符合 DSM-V 妥瑞氏症诊断标准的 5 至 18 岁儿童患者。患者在试验开始前、随机分组后 1 个月和 2 个月进行评估。主要结局指标采用耶鲁综合抽动严重程度量表（YGTSS）评估，次要结局指标研究这些儿童的可能共病情况。结果显示，对照组和 PS128 组在 YGTSS 改善方面无显著差异。至于次要终点，对康纳斯持续操作测试（CPT）的分析显示 PS128 组在错误和可察觉性方面有所改善。总之，尽管益生菌对妥瑞氏症儿童的抽动症状可能没有减轻作用，但对注意力缺陷多动障碍（ADHD）等共病可能有一定益处。需要进一步研究来阐明益生菌对妥瑞氏症儿童共病的影响。
