Department of Ophthalmology, Medical Faculty and University Hospital of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Department of Ophthalmology, St. Martinus-Krankenhaus Düsseldorf, Gladbacher Str. 26, 40219, Düsseldorf, Germany.
Int Ophthalmol. 2024 Apr 16;44(1):182. doi: 10.1007/s10792-024-03109-6.
BACKGROUND/AIMS: This work aimed to investigate changes in optic nerve head (ONH) morphometry based on Bruch membrane opening in children with extensive nocturnal intraocular pressure (IOP) elevations.
The course of Bruch membrane opening-based optic nerve head (ONH) morphometry was analysed in thirty-two patients younger than 18 years with evaluable SD-OCT examinations of the ONH and nocturnal posture-dependent IOP elevation above 25 mmHg. Longitudinal changes in neuroretinal rim tissue, as measured by Bruch Membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness, were assessed.
One year after the 24 h IOP measurement, global BMO-MRW (- 1.61 ± 16.8 µm, n.s.; p = 0.611) and RNFL (+ 0.64 ± 3.17 µm; n.s.; p = 0.292) measurements were not significantly different from the baseline. No significant BMO-MRW reduction (- 3.91 ± 24.3 µm; n.s. p = 0.458) or deviation in RNFL thickness (+ 1.10 ± 3.52 µm) was observed at the four-year follow-up. Absolute IOP values measured in the supine position did not correlate with changes in global BMO-MRW or RNFL thickness.
Posture-dependent IOP elevations do not seem to influence retinal nerve fibre layer thickness or Bruch membrane opening-based morphometric data in childhood.
背景/目的：本研究旨在探讨广泛夜间眼压升高儿童的神经眼窝（ONH）形态变化是否与 Bruch 膜开口有关。
对 32 名年龄小于 18 岁且具有可评估的 SD-OCT 视神经头和夜间体位依赖性眼压升高超过 25mmHg 的患者进行研究。通过 Bruch 膜开口最小边缘宽度（BMO-MRW）和视神经周围视网膜神经纤维层（RNFL）厚度测量，分析基于 Bruch 膜开口的视神经头（ONH）形态的变化过程。
在 24 小时眼压测量后 1 年，全球 BMO-MRW（-1.61±16.8μm，无统计学差异；p=0.611）和 RNFL（+0.64±3.17μm，无统计学差异；p=0.292）测量值与基线无显著差异。在 4 年随访时，BMO-MRW 也没有明显减少（-3.91±24.3μm，无统计学差异；p=0.458），RNFL 厚度也没有明显增加（+1.10±3.52μm）。仰卧位测量的绝对眼压值与全球 BMO-MRW 或 RNFL 厚度的变化无相关性。
体位依赖性眼压升高似乎不会影响儿童的视网膜神经纤维层厚度或基于 Bruch 膜开口的形态计量数据。
