Clinical College of Ophthalmology, Tianjin Medical University, No. 4 Gansu Road, Heping District, Tianjin, 300020, China.
Department of Ophthalmology, The 1St People's Hospital of Yunnan Province, 157 Jinbi Road, Kunming, China.
Int Ophthalmol. 2021 Aug;41(8):2817-2825. doi: 10.1007/s10792-021-01838-6. Epub 2021 Apr 11.
To analyze intraocular pressure (IOP) and glaucoma-associated factors in children.
A total of 4438 children aged 7-16 years (2321 boys and 2117 girls) were included in this study. Various ophthalmologic [IOP, central corneal thickness (CCT), etc.] and demographic (body mass index, etc.) parameters were evaluated.
IOP increased between the ages of 7 and 9 years, peaking at 9 years. IOP increased after reaching a trough at 11 years and subsequently stabilized after 14 years. Girls exhibited thinner CCT (534.28 ± 30.84 µm vs. 537.04 ± 31.33 µm, P = 0.003), thicker lens thickness (3.56 ± 0.21 mm vs. 3.54 ± 0.20 mm, P = 0.001), shorter axial length (22.91 ± 0.93 mm vs. 23.32 ± 0.89 mm, P < 0.001), shallower anterior chamber depth (2.92 ± 0.27 mm vs. 3.00 ± 0.26 mm, P < 0.001), higher refraction (- 0.57 ± 1.48 D vs. 0.16 ± 1.35 D, P < 0.001), and higher mean corneal curvature (43.77 ± 1.39 vs. 43.03 ± 1.35, P < 0.001). Multivariable analysis assessed the following IOP-associated factors: thicker CCT [standardized correlation coefficient (SRC) = 0.201, P < 0.001), deeper anterior chamber depth (SRC = 0.059, P = 0.009), shorter axial length (SRC = - 0.086, P = 0.036), lower mean corneal curvature (SRC = - 0.123, P < 0.001), higher refraction (SRC = - 0.090, P < 0.001).
IOP fluctuated in children, and a trend toward a higher mean IOP between the ages of 9 and 11 years, which stabilized after 14 years, was observed. IOP was associated with CCT, anterior chamber depth, axial length, lens thickness, mean corneal curvature, spherical equivalent, and systolic blood pressure.
分析儿童的眼压（IOP）和青光眼相关因素。
本研究纳入了 4438 名 7-16 岁的儿童（男 2321 名，女 2117 名）。评估了各种眼科[IOP、中央角膜厚度（CCT）等]和人口统计学（体重指数等）参数。
IOP 在 7-9 岁之间增加，在 9 岁时达到峰值。在 11 岁时达到低谷后，IOP 增加，随后在 14 岁后稳定。女孩的 CCT 更薄（534.28 ± 30.84 µm 比 537.04 ± 31.33 µm，P=0.003），晶状体厚度更厚（3.56 ± 0.21 mm 比 3.54 ± 0.20 mm，P=0.001），眼轴更短（22.91 ± 0.93 mm 比 23.32 ± 0.89 mm，P<0.001），前房深度更浅（2.92 ± 0.27 mm 比 3.00 ± 0.26 mm，P<0.001），屈光度更高（-0.57 ± 1.48 D 比 0.16 ± 1.35 D，P<0.001），平均角膜曲率更高（43.77 ± 1.39 比 43.03 ± 1.35，P<0.001）。多变量分析评估了以下与 IOP 相关的因素：更厚的 CCT（标准化相关系数（SRC）=0.201，P<0.001），更深的前房深度（SRC=0.059，P=0.009），更短的眼轴（SRC=-0.086，P=0.036），更低的平均角膜曲率（SRC=-0.123，P<0.001），更高的屈光度（SRC=-0.090，P<0.001）。
儿童的 IOP 波动，9-11 岁之间存在平均 IOP 升高的趋势，14 岁后稳定。IOP 与 CCT、前房深度、眼轴、晶状体厚度、平均角膜曲率、等效球镜和收缩压有关。
