Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Gut Microbes. 2024 Jan-Dec;16(1):2340487. doi: 10.1080/19490976.2024.2340487. Epub 2024 Apr 16.
Obesity is becoming a major global health problem in children that can cause diseases such as type 2 diabetes and metabolic disorders, which are closely related to the gut microbiota. However, the underlying mechanism remains unclear. In this study, a significant positive correlation was observed between and obesity in children ( = 0.003). Next, the effect of on obesity was explored by using fecal microbiota transplantation (FMT) experiment. Transplantation of . increased serum levels of fasting blood glucose ( < 0.01), insulin ( < 0.01) and interleukin-1β (IL-1β) ( < 0.05) in high-fat diet (HFD)-induced obese mice, but not in normal mice. Characterization of the gut microbiota indicated that reduced the relative abundance of the genus in mice ( < 0.01). Further analysis on bile acids (BAs) revealed that increased the primary BAs and ursodeoxycholic acid (UDCA) in HFD-induced mice ( < 0.05). This study demonstrated for the first time that has a significant positive correlation with obesity in children, and can increase fasting blood glucose and insulin levels in HFD-fed obese mice, which are related to the abundance of genus and bile acids.
肥胖正在成为全球儿童面临的一个主要健康问题，它可导致 2 型糖尿病和代谢紊乱等疾病，这些疾病与肠道微生物群密切相关。然而，其潜在机制尚不清楚。在本研究中，观察到儿童中 与肥胖呈显著正相关（r=0.003）。接下来，通过粪便微生物群移植（FMT）实验探索了 对肥胖的影响。. 的移植增加了高脂肪饮食（HFD）诱导肥胖小鼠的空腹血糖（ < 0.01）、胰岛素（ < 0.01）和白细胞介素-1β（IL-1β）（ < 0.05）的血清水平，但对正常小鼠没有影响。肠道微生物群的特征表明，. 减少了小鼠中 属的相对丰度（ < 0.01）。对胆汁酸（BAs）的进一步分析表明，. 增加了 HFD 诱导小鼠中的初级 BAs 和熊去氧胆酸（UDCA）（ < 0.05）。本研究首次证明 与儿童肥胖呈显著正相关，可增加 HFD 喂养肥胖小鼠的空腹血糖和胰岛素水平，这与 属和胆汁酸的丰度有关。
