Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou 350002, China.
Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Int J Mol Sci. 2022 May 25;23(11):5905. doi: 10.3390/ijms23115905.
High-amylose corn starch is well known for its anti-obesity activity, which is mainly based on the regulatory effects on gut microbiota. Recently, the gut microbiota has been reported to improve metabolic health by altering circulating bile acids. Therefore, in this study, the influence of high-amylose corn starch (HACS) on intestinal microbiota composition and serum bile acids was explored in mice fed with a high fat diet (HFD). The results demonstrated HACS treatment reduced HFD-induced body weight gain, hepatic lipid accumulation, and adipocyte hypertrophy as well as improved blood lipid profiles. Moreover, HACS also greatly impacted the gut microbiota with increased and decreased relative abundance being observed. Furthermore, compared to ND-fed mice, the mice with HFD feeding exhibited more obvious changes in serum bile acids profiles than the HFD-fed mice with the HACS intervention, showing HACS might restore HFD-induced alterations to bile acid composition in blood. In summary, our results suggested that the underlying mechanisms of anti-obesity activity of HACS may involve its regulatory effects on gut microbiota and circulating bile acids.
高直链玉米淀粉以其抗肥胖活性而闻名，其主要作用机制是对肠道微生物群的调节。最近有报道称，肠道微生物群通过改变循环胆汁酸来改善代谢健康。因此，本研究旨在探讨高直链玉米淀粉（HACS）对高脂饮食（HFD）喂养小鼠肠道微生物群组成和血清胆汁酸的影响。结果表明，HACS 处理可减轻 HFD 诱导的体重增加、肝脂质积累和脂肪细胞肥大，并改善血脂谱。此外，HACS 还极大地影响了肠道微生物群，观察到 和 的相对丰度增加和减少。此外，与 ND 喂养的小鼠相比，HFD 喂养的小鼠的血清胆汁酸谱变化比 HACS 干预的 HFD 喂养的小鼠更为明显，表明 HACS 可能恢复 HFD 诱导的血液胆汁酸组成的改变。综上所述，我们的研究结果表明，HACS 抗肥胖活性的潜在机制可能与其对肠道微生物群和循环胆汁酸的调节作用有关。
