Ren Shuyu, Pan Fangfang, Jin Jie
Rehabilitation Department, Linping Campus, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Neurol. 2024 Apr 2;15:1371298. doi: 10.3389/fneur.2024.1371298. eCollection 2024.
Alzheimer's disease (AD) is the most prevalent type of dementia and represents 60-80% of dementia cases. AD affects over 32 million people globally, and 8.1% of affected females and 5.4% of affected males were older than 65 years. Cognitive rehabilitation focuses on helping patients develop individualized strategies to obtain or maintain optimal functioning. As of now, there is no complete and systematic meta-analysis on the effects of cognitive rehabilitation on cognitive functioning in AD patients.
To provide the most recent and extensive pooled analysis and evidence and explore the influence of cognitive rehabilitation on overall cognitive functioning in patients with AD.
We searched articles through several databases such as PubMed, Cochrane Library, Embase, and Web of Science, from the inception to June 2023. Studies on cognitive stimulation, cognitive training, and cognitive interventions, and non-English articles were excluded. The outcome measures encompassed the effects of cognitive rehabilitation on the overall cognitive functioning of people with AD (e.g., verbal fluency, behavioral memory, neuropsychiatric status and occupational performance levels).
A total of 14 clinical trials were included in this analysis. The meta-analysis showed that cognitive rehabilitation significantly improved quality of life (WMD: 2.87; 95% CI: 0.79, 4.95; = 0.007) and occupational performance levels (WMD: 1.53; 95% CI: 0.43, 2.63; = 0.007) in patients with AD. However, it did not show a significant effect on other domains of specific cognitive functions in patients with AD.
Cognitive rehabilitation exhibited a moderate to large impact on both quality of life and occupational performance levels in people with AD. Future studies are required to explore the potential of various cognitive interventions across specific domains, so as to provide more insights into the management of AD.
https://www.crd.york.ac.uk/prospero/, identifier CRD42023444390.
阿尔茨海默病（AD）是最常见的痴呆类型，占痴呆病例的60 - 80%。全球有超过3200万人受AD影响，65岁以上的女性患者占8.1%，男性患者占5.4%。认知康复专注于帮助患者制定个性化策略以获得或维持最佳功能。截至目前，尚无关于认知康复对AD患者认知功能影响的完整且系统的荟萃分析。
提供最新且广泛的汇总分析和证据，并探讨认知康复对AD患者整体认知功能的影响。
我们通过PubMed、Cochrane图书馆、Embase和Web of Science等多个数据库检索了从创刊至2023年6月的文章。排除了关于认知刺激、认知训练和认知干预的研究以及非英文文章。结局指标包括认知康复对AD患者整体认知功能的影响（如语言流畅性、行为记忆、神经精神状态和职业表现水平）。
本分析共纳入14项临床试验。荟萃分析表明，认知康复显著改善了AD患者的生活质量（加权均数差：2.87；95%置信区间：0.79，4.95；P = 0.007）和职业表现水平（加权均数差：1.53；95%置信区间：0.43，2.63；P = 0.007）。然而，它对AD患者特定认知功能的其他领域未显示出显著影响。
认知康复对AD患者的生活质量和职业表现水平具有中度至较大影响。未来需要开展研究探索特定领域各种认知干预的潜力，以便为AD的管理提供更多见解。
