Russo A, Tomarchio S, Pero G, Consoli G, Marina R, Rizzari C, Schilirò G
Med Pediatr Oncol. 1985;13(6):313-7. doi: 10.1002/mpo.2950130603.
Visual-evoked potentials (VEPs) were studied in 55 asymptomatic children with leukemia or solid tumors in remission in order to detect subclinical demyelination of the optic pathway after CNS prophylaxis. In group I (11 patients with ALL studied prospectively), VEP latency was increased in ten after cranial radiation (CR) as compared with previous values. Group II (18 patients with ALL in maintenance) and group III (16 patients with ALL off therapy) were studied retrospectively and VEP latency was found above normal limits in 33 and 31%, respectively. In group IV (four patients with solid tumors and six with leukemia, all of whom received no CR), VEP latency was normal despite periodical intrathecal methotrexate administrations to five of them. We conclude that CR determines a slowing of conduction on VEP test, probably due to demyelination of the optic pathway, in a high proportion of patients. The future clinical significance of these findings must be established throughout a prolonged follow-up period.
对55例处于缓解期的无症状白血病或实体瘤患儿进行了视觉诱发电位（VEP）研究，以检测中枢神经系统预防治疗后视神经通路的亚临床脱髓鞘情况。在第一组（前瞻性研究的11例急性淋巴细胞白血病患者）中，与先前值相比，10例接受颅脑放疗（CR）后的VEP潜伏期延长。第二组（18例处于维持期的急性淋巴细胞白血病患者）和第三组（16例停止治疗的急性淋巴细胞白血病患者）进行了回顾性研究，发现VEP潜伏期分别在33%和31%的患者中高于正常范围。在第四组（4例实体瘤患者和6例白血病患者，均未接受CR）中，尽管其中5例定期鞘内注射甲氨蝶呤，但VEP潜伏期仍正常。我们得出结论，在很大比例的患者中，CR导致VEP检测的传导减慢，可能是由于视神经通路脱髓鞘所致。这些发现的未来临床意义必须通过长期随访来确定。
