Mashaba Given R, Mokgalaboni Kabelo, Lebelo Sogolo L
DIMAMO Population Health Research Centre, University of Limpopo, Sovenga 0727, South Africa.
Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Roodepoort 1710, South Africa.
Antioxidants (Basel). 2025 Aug 14;14(8):997. doi: 10.3390/antiox14080997.
There is increasing use of modern medicine globally to manage cardiovascular diseases (CVDs). However, many people, especially in low-to-middle-income countries, still rely on traditional medicinal plants for their daily health needs. However, limited studies have explored the use of these remedies. Therefore, this narrative review aimed to evaluate the potential of () in managing diabetes, dyslipidemia, inflammation, and hypertension, including its effects on oxidative stress. This study reviewed evidence from PubMed, Web of Science, and ResearchGate, published in these databases up to 30 April 2025. The evidence showed that had the potential to preserve cardiometabolic health and reduce CVD-associated risk factors. Notably, improved glucose metabolism, inflammation, hypertension, and oxidative stress. This plant exhibits antihyperglycemic effects by activating adenosine monophosphate-activated protein kinase (AMPK) and inhibiting gluconeogenesis and the activities of carbohydrase. It also ameliorates dyslipidemia by modulating the activities of peroxisome proliferator-activated receptor alpha (PPARα) and increasing fatty acid oxidation. The anti-inflammatory potential of is modulated by the activation of PPARα, which inhibits nuclear factor kappa beta (NF-κβ) and decreases the production of inflammatory cytokines. Its antioxidant property is attributed to its ability to increase antioxidant enzymes like catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH), which are known to counteract oxidative damage. However, it is important to note that different parts of the plant had varying impacts on CVD risk factors, depending on whether the study was conducted preclinically or clinically. Therefore, its extract should be explored as a potential remedy for the management of CVD risk factors, especially in areas where access to healthcare is limited.
全球范围内现代医学在管理心血管疾病（CVDs）方面的应用日益增加。然而，许多人，尤其是中低收入国家的人们，仍然依靠传统药用植物来满足日常健康需求。然而，对这些疗法的使用进行探索的研究有限。因此，本叙述性综述旨在评估（）在管理糖尿病、血脂异常、炎症和高血压方面的潜力，包括其对氧化应激的影响。本研究回顾了截至2025年4月30日在PubMed、科学网和ResearchGate上发表的这些数据库中的证据。证据表明，（）有潜力维护心脏代谢健康并降低与心血管疾病相关的风险因素。值得注意的是（）改善了葡萄糖代谢、炎症、高血压和氧化应激。这种植物通过激活腺苷单磷酸激活蛋白激酶（AMPK）并抑制糖异生和碳水化合物酶的活性来发挥抗高血糖作用。它还通过调节过氧化物酶体增殖物激活受体α（PPARα）的活性并增加脂肪酸氧化来改善血脂异常。（）的抗炎潜力是通过PPARα的激活来调节的，PPARα抑制核因子κB（NF-κβ）并减少炎症细胞因子的产生。其抗氧化特性归因于其增加过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽（GSH）等抗氧化酶的能力，这些酶已知可抵消氧化损伤。然而，需要注意的是，根据研究是在临床前还是临床进行，植物的不同部位对心血管疾病风险因素有不同的影响。因此，应探索其提取物作为管理心血管疾病风险因素的潜在疗法，特别是在医疗保健获取有限的地区。
