Zhang Haomin, Chen Haoran, Zhang Jundong, Chen Ximeng, Guo Bin, Zhi Peng, Li Zhuoyang, Liu Geliang, Yang Bo, Chi Xiaohua, Wang Yixing, Cao Feng, Ren Jun, Lu Xuechun
Department of Hematology, the Second Medical Center of the China PLA General Hospital & National Center for Clinical Medicine of Geriatric Diseases, Beijing, China.
Management School, Shanxi Medical University, Taiyuan, China.
Emerg Crit Care Med. 2021 Sep 15;1(1):20-28. doi: 10.1097/EC9.0000000000000005. eCollection 2021 Sep.
Severe acute respiratory syndrome coronavirus 2 is a highly contagious viral infection, without any available targeted therapies. The high mortality rate of COVID-19 is speculated to be related to immune damage.
In this study, clinical bioinformatics analysis was conducted on transcriptome data of coronavirus infection.
Bioinformatics analysis revealed that the complex immune injury induced by coronavirus infection provoked dysfunction of numerous immune-related molecules and signaling pathways, including immune cells and toll-like receptor cascades. Production of numerous cytokines through the Th17 signaling pathway led to elevation in plasma levels of cytokines (including , , and -α) followed by concurrent inflammatory storm, which mediates the autoimmune response. Several novel medications seemed to display therapeutic effects on immune damage associated with coronavirus infection.
This study provided insights for further large-scale studies on the target therapy on reconciliation of immunological damage associated with COVID-19.
严重急性呼吸综合征冠状病毒2是一种具有高度传染性的病毒感染，目前尚无任何可用的靶向治疗方法。据推测，2019冠状病毒病的高死亡率与免疫损伤有关。
在本研究中，对冠状病毒感染的转录组数据进行了临床生物信息学分析。
生物信息学分析表明，冠状病毒感染引起的复杂免疫损伤导致众多免疫相关分子和信号通路功能障碍，包括免疫细胞和Toll样受体级联反应。通过Th17信号通路产生的多种细胞因子导致血浆中细胞因子（包括 、 和 -α）水平升高，随后并发炎症风暴，介导自身免疫反应。几种新型药物似乎对与冠状病毒感染相关的免疫损伤具有治疗作用。
本研究为进一步大规模研究针对2019冠状病毒病相关免疫损伤的靶向治疗提供了见解。
