Digestive Health Institute, AdventHealth Tampa, Tampa, FL, USA.
Stanford University, Palo Alto, CA, USA.
Surg Endosc. 2024 May;38(5):2331-2343. doi: 10.1007/s00464-024-10806-x. Epub 2024 Apr 17.
The use of hemostatic agents by general surgeons during abdominal operations is commonplace as an adjunctive measure to minimize risks of postoperative bleeding and its downstream complications. Proper selection of products can be hampered by marginal understanding of their pharmacokinetics and pharmacodynamics. While a variety of hemostatic agents are currently available on the market, the choice of those products is often confusing for surgeons. This paper aims to summarize and compare the available hemostatic products for each clinical indication and to ultimately better guide surgeons in the selection and proper use of hemostatic agents in daily clinical practice.
We utilized PubMed electronic database and published product information from the respective pharmaceutical companies to collect information on the characteristics of the hemostatic products.
All commercially available hemostatic agents in the US are described with a description of their mechanism of action, indications, contraindications, circumstances in which they are best utilized, and expected results.
Hemostatic products come with many different types and specifications. They are valuable tools to serve as an adjunct to surgical hemostasis. Proper education and knowledge of their characteristics are important for the selection of the right agent and optimal utilization.
普通外科医生在腹部手术中使用止血剂作为辅助措施来尽量减少术后出血及其下游并发症的风险是很常见的。由于对其药代动力学和药效学的了解有限，产品的正确选择可能会受到阻碍。虽然目前市场上有多种止血剂，但对于外科医生来说，选择这些产品往往令人困惑。本文旨在总结和比较每种临床适应证的可用止血产品，并最终更好地指导外科医生在日常临床实践中选择和正确使用止血剂。
我们利用 PubMed 电子数据库和各制药公司发布的产品信息收集止血剂产品特性的信息。
美国所有市售的止血剂均描述了其作用机制、适应证、禁忌证、最佳应用情况和预期效果。
止血剂有许多不同的类型和规格。它们是作为外科止血辅助手段的有价值的工具。适当的教育和对其特性的了解对于选择正确的制剂和最佳利用是很重要的。
