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基于生物材料的策略增强糖尿病创面愈合中的血管生成。

Biomaterials-Based Strategies to Enhance Angiogenesis in Diabetic Wound Healing.

机构信息

Department of Veterinary Surgery and Radiology, West Bengal University of Animal & Fishery Sciences, Kolkata 700037, India.

Department of Veterinary Clinical Complex, West Bengal University of Animal & Fishery Sciences, Kolkata 700037, India.

出版信息

ACS Biomater Sci Eng. 2024 May 13;10(5):2725-2741. doi: 10.1021/acsbiomaterials.4c00216. Epub 2024 Apr 17.

DOI:10.1021/acsbiomaterials.4c00216
PMID:38630965
Abstract

Amidst the present healthcare issues, diabetes is unique as an emerging class of affliction with chronicity in a majority of the population. To check and control its effects, there have been huge turnover and constant development of management strategies, and though a bigger part of the health care area is involved in achieving its control and the related issues such as the effect of diabetes on wound healing and care and many of the works have reached certain successful outcomes, still there is a huge lack in managing it, with maximum effect yet to be attained. Studying pathophysiology and involvement of various treatment options, such as tissue engineering, application of hydrogels, drug delivery methods, and enhancing angiogenesis, are at constantly developing stages either direct or indirect. In this review, we have gathered a wide field of information and different new therapeutic methods and targets for the scientific community, paving the way toward more settled ideas and research advances to cure diabetic wounds and manage their outcomes.

摘要

在当前的医疗保健问题中,糖尿病是一种独特的新兴疾病类别,大多数人都会患上这种慢性病。为了检查和控制其影响,管理策略已经发生了巨大的变化和不断的发展,尽管医疗保健领域的大部分都参与到了糖尿病的控制及其相关问题的管理中,例如糖尿病对伤口愈合和护理的影响,并且许多工作已经取得了一定的成功,但在管理糖尿病方面仍然存在巨大的不足,最大的效果还没有达到。研究病理生理学和各种治疗选择的参与,如组织工程、水凝胶的应用、药物输送方法和促进血管生成,无论是直接的还是间接的,都处于不断发展的阶段。在这篇综述中,我们收集了广泛的信息和不同的新治疗方法和靶点,为科学界提供了信息,为更稳定的治疗理念和研究进展铺平了道路,以治愈糖尿病性伤口并管理其结果。

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