在接受体外循环冠状动脉旁路移植术的稳定型冠状动脉疾病患者中，全免疫炎症值与主要心血管和脑血管事件之间的关系。

Relationship between pan-immune- inflammation value and in major cardiovascular and cerebrovascular events in stable coronary artery disease patients undergoing on-pump coronary artery bypass graft surgery.

机构信息

Department of Cardiovascular Surgery, Balikesir University Faculty of Medicine, Balikesir, Turkey.

Department of Cardiology, Balikesir University Faculty of Medicine, Balikesir, Turkey.

出版信息

J Cardiothorac Surg. 2024 Apr 17;19(1):241. doi: 10.1186/s13019-024-02691-1.

DOI:10.1186/s13019-024-02691-1

PMID:38632613

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11022406/

Abstract

BACKGROUND

In this study, we aimed to evaluate the association of pan-immune-inflammation value (PIV) with major cardiovascular and cerebrovascular events (MACCE) in stable coronary artery disease patients undergoing on-pump coronary artery bypass graft (CABG) surgery.

METHODS

We retrospectively analyzed data from 527 patients who underwent on-pump CABG surgery for stable coronary artery disease between June 2015 and December 2020. Patients were categorized into two groups based on MACCE development. PIV levels were calculated from blood samples taken on admission. PIV was calculated as [neutrophil count (×10/µL)×platelet count (×10/µL))×monocyte count (×10/µL)]/lymphocyte count (×10/µL). The primary endpoint was long-term major cardiovascular and cerebrovascular events (MACCE) at a median follow-up of 4.6 years.

RESULTS

Of the included patients, 103 (19.5%) developed MACCE. PIV was higher in patients with MACCE compared to those without (470.8 [295.3-606.8] vs. 269.8 [184.3-386.4], p < 0.001). Multivariate analysis showed a significant positive association between PIV and MACCE (HR: 1.326, 95%CI:1.212-1452, p < 0.001). The cut-off value for the PIV in the estimation of MACCE was 368.28 ( AUC: 0.726 with 69% sensitivity, 71% specificity, p < 0.001).

CONCLUSION

This study shows a significant link between high PIV levels and MACCE in stable coronary artery disease patients undergoing on-pump CABG surgery. Our findings suggest that PIV may be a valuable, routinely available, and inexpensive marker for identifying patients at increased risk of MACCE.

摘要

背景

本研究旨在评估全免疫炎症值（PIV）与接受体外循环冠状动脉旁路移植术（CABG）的稳定型冠状动脉疾病患者主要心脑血管不良事件（MACCE）之间的相关性。

方法

我们回顾性分析了 2015 年 6 月至 2020 年 12 月期间接受体外循环 CABG 手术治疗稳定型冠状动脉疾病的 527 例患者的数据。根据 MACCE 发生情况将患者分为两组。入院时采集血样计算 PIV 水平。PIV 计算方法为[中性粒细胞计数（×10/µL）×血小板计数（×10/µL））×单核细胞计数（×10/µL）]/淋巴细胞计数（×10/µL）。主要终点为中位随访 4.6 年后的长期主要心脑血管不良事件（MACCE）。

结果

在纳入的患者中，有 103 例（19.5%）发生 MACCE。与无 MACCE 患者相比，MACCE 患者的 PIV 更高（470.8[295.3-606.8] vs. 269.8[184.3-386.4]，p<0.001）。多变量分析显示，PIV 与 MACCE 之间存在显著正相关（HR：1.326，95%CI：1.212-1452，p<0.001）。PIV 预测 MACCE 的截断值为 368.28（AUC：0.726，敏感性 69%，特异性 71%，p<0.001）。