Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
Department of Theriogenology, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
Open Vet J. 2024 Jan;14(1):25-31. doi: 10.5455/OVJ.2024.v14.i1.4. Epub 2024 Jan 31.
Affection with (C. pseudotuberculosis) and development of cellulitis and/or abscess formation with cutaneous lymphangitis in cattle is rare to some extent, so literature about the biochemical changes that would accompany this infection is rare.
In this context, the present study was designed to screen the effect of the infection with C. cutaneous lymphangitis on the release of some immune molecules, organ functions, and redox state in Baladi cows.
Fourteen Baladi cows from a small dairy farm in El-Behira, Egypt, were selected to complete this study. After bacteriological culture confirmation, seven of them were found suffering from cutaneous lesions due to infection with C. (Diseased group), while the others were healthy (Healthy group). Serum samples were obtained to evaluate the presumptive changes in some clinicopathological parameters.
Serum analysis revealed a significant decrease in the levels of interferon-gamma and interleukin-17 as well as a significant decrement in the concentration of beta-defensin (β-defensin) and lipocalin-2. While serum level of interleukin-10 recorded a significant increase in these animals when compared to healthy control animals. Concurrently, the affected animals recorded a significant elevation in serum levels of hepato-cardiac enzymes, urea, and creatinine in addition to disturbance in the serum redox state.
In conclusion, infection with C. cattle may disturb the defensive immune state, body organ function, and redox state of the animals.
牛感染（假结核棒状杆菌）并发展为蜂窝织炎和/或伴有皮肤淋巴管炎的脓肿形成在一定程度上较为罕见，因此关于伴随这种感染的生化变化的文献很少。
在这种情况下，本研究旨在筛选牛感染假结核棒状杆菌对某些免疫分子、器官功能和氧化还原状态释放的影响。
从埃及贝尼苏韦夫的一个小型奶牛场选择了 14 头 Baladi 奶牛来完成这项研究。经过细菌培养确认后，其中 7 头患有因感染假结核棒状杆菌引起的皮肤病变（患病组），而其他牛则健康（健康组）。采集血清样本以评估一些临床病理参数的变化。
血清分析显示干扰素-γ和白细胞介素-17水平显著下降，β-防御素（β-防御素）和脂钙素-2浓度显著降低。而这些动物的白细胞介素-10 血清水平与健康对照组相比显著增加。同时，受感染的动物的血清肝心脏酶、尿素和肌酐水平显著升高，以及血清氧化还原状态紊乱。
总之，牛感染假结核棒状杆菌可能会扰乱动物的防御性免疫状态、身体器官功能和氧化还原状态。
