Department of Electrical Engineering, National Taiwan University, Taipei City 10617, Taiwan.
Department of Neurology, Taipei Veteran General Hospital, Taipei City 11217, Taiwan.
ACS Chem Neurosci. 2024 May 1;15(9):1728-1731. doi: 10.1021/acschemneuro.4c00198. Epub 2024 Apr 18.
Ultrasound neuromodulation is a potential alternative therapy for suppressing epileptic discharges. Recently, several human clinical trials have reported promising results from repeated focused ultrasound (FUS) treatments for temporal lobe epilepsy. In this Viewpoint, we highlight the valuable guidance of preclinical validation methods for choosing the optimal FUS parameters, thus ensuring consistency with the outcomes of clinical trials and leading human trials to the safest and most effective approaches.
超声神经调控是一种抑制癫痫发作的潜在替代疗法。最近，几项针对颞叶癫痫的重复聚焦超声（FUS）治疗的人体临床试验报告了有希望的结果。在本观点中，我们强调了临床前验证方法的宝贵指导作用，以选择最佳的 FUS 参数，从而确保与临床试验结果保持一致，并使人体试验采用最安全和最有效的方法。
