Kaudewitz P, Ruzicka T, Meurer M, Rieber P, Braun-Falco O
Arch Dermatol Res. 1985;277(6):444-7. doi: 10.1007/BF00510060.
It has been suggested that aberrant expression of HLA-DR plays an important role in the induction of an autoimmune reaction. In lupus erythematosus (LE), skin represents a major target for autoimmune attack. We therefore tested lesional and nonlesional skin from 11 patients with different clinical subtypes of LE for the presence of HLA-DR molecules on keratinocytes using a monoclonal antibody against a non-polymorphic HLA-DR determinant. In all lesions tested, HLA-DR-positive keratinocytes were present, whereas in nonlesional skin, these cells remained HLA-DR negative. To exclude the possibility of passive absorption of DR molecules, the de novo synthesis of HLA-DR was demonstrated by the presence of cytoplasmic HLA-DR gamma chains in keratinocytes. If aberrant HLA-DR expression is a primary event, it could facilitate the recognition of autoantigens on keratinocytes by immunocompetent cells. Alternatively, the synthesis of DR molecules could be induced as a secondary event by mediators derived from the inflammatory infiltrate.
有人提出，HLA - DR的异常表达在自身免疫反应的诱导中起重要作用。在红斑狼疮（LE）中，皮肤是自身免疫攻击的主要靶点。因此，我们使用针对非多态性HLA - DR决定簇的单克隆抗体，检测了11例不同临床亚型LE患者的皮损和非皮损皮肤中角质形成细胞上HLA - DR分子的存在情况。在所有检测的皮损中，均存在HLA - DR阳性角质形成细胞，而在非皮损皮肤中，这些细胞仍为HLA - DR阴性。为排除DR分子被动吸收的可能性，通过角质形成细胞中细胞质HLA - DRγ链的存在证明了HLA - DR的从头合成。如果异常的HLA - DR表达是一个原发性事件，它可能会促进免疫活性细胞对角质形成细胞上自身抗原的识别。或者，DR分子的合成可能是由炎症浸润产生的介质作为继发性事件诱导的。
