人类角质形成细胞在疾病中进行HLA - DR抗原生物合成的证据。
Evidence of HLA-DR antigen biosynthesis by human keratinocytes in disease.
作者信息
Volc-Platzer B, Majdic O, Knapp W, Wolff K, Hinterberger W, Lechner K, Stingl G
出版信息
J Exp Med. 1984 Jun 1;159(6):1784-9. doi: 10.1084/jem.159.6.1784.
Abstract
As opposed to normal human skin where HLA-DR expression is restricted to the Langerhans cell (LC) population, HLA-DR, but not HLA-DS antigens can be readily detected on keratinocytes (KC) in certain disease states, i.e., cutaneous T cell lymphoma (CTCL), graft-vs-host disease (GVHD), and lichen planus (LP). To clarify the cellular origin of KC-bound HLA-DR antigens, we used a monoclonal antibody directed against determinants solely expressed on the cytoplasmic HLA-DR gamma chain (VIC-Y1) and observed that, by immunofluorescence, KC displaying HLA-DR alpha/beta complexes on their surface uniformly displayed cytoplasmic VIC-Y1 reactivity. In view of the crucial role of the gamma chain for HLA-DR biosynthesis, we conclude that HLA-DR antigens on KC are actively synthesized by these cells.
摘要
与正常人类皮肤不同，在正常皮肤中HLA - DR的表达仅限于朗格汉斯细胞（LC）群体，而在某些疾病状态下，即皮肤T细胞淋巴瘤（CTCL）、移植物抗宿主病（GVHD）和扁平苔藓（LP）中，角质形成细胞（KC）上可以很容易地检测到HLA - DR抗原，但检测不到HLA - DS抗原。为了阐明与KC结合的HLA - DR抗原的细胞来源，我们使用了一种针对仅在细胞质HLA - DRγ链上表达的决定簇的单克隆抗体（VIC - Y1），并通过免疫荧光观察到，在其表面显示HLA - DRα/β复合物的KC均一地显示出细胞质VIC - Y1反应性。鉴于γ链对HLA - DR生物合成的关键作用，我们得出结论，KC上的HLA - DR抗原是由这些细胞主动合成的。
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