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口腔健康与心脏和血管健康的关系:基于人群的研究。

Role of oral health in heart and vascular health: A population-based study.

机构信息

Department of Health Informatics, Institute of Health Sciences, Faculty of Health Sciences, University of Debrecen, Debrecen, Hungary.

Department of Community Dentistry, Faculty of Dentistry, Semmelweis University, Budapest, Hungary.

出版信息

PLoS One. 2024 Apr 18;19(4):e0301466. doi: 10.1371/journal.pone.0301466. eCollection 2024.

Abstract

BACKGROUND AND AIM

Conditions such as hypertension, cardiovascular diseases, and hypercholesterolemia, are a major public health challenge. This study investigates the influence of oral health indicators, including gum bleeding, active dental caries, tooth mobility, and tooth loss, on their prevalence in Hungary, considering socioeconomic, demographic, and lifestyle factors.

MATERIALS AND METHODS

Data from the 2019 Hungarian European Health Interview Survey with 5,603 participants informed this analysis. Data were accessed from the records maintained by the Department of Health Informatics at the University of Debrecen between September and November 2023. Variable selection employed elastic net regularization and k-fold cross-validation, leading to high-performing predictors for weighted multiple logistic regression models. Sensitivity analysis confirmed the findings' validity.

RESULTS

Significant links were found between poor oral health and chronic cardiac conditions. Multiple teeth extractions increased hypertension risk (OR = 1.67, 95% CI: [1.01-2.77]); dental prosthetics had an OR of 1.45 [1.20-1.75]. Gum bleeding was associated with higher cardiovascular disease (OR = 1.69 [1.30-2.21]) and hypercholesterolemia risks (OR = 1.40 [1.09-1.81]).

CONCLUSIONS

Oral health improvement may reduce the risk of cardiac conditions. This underscores oral health's role in multidisciplinary disease management.

摘要

背景与目的

高血压、心血管疾病和高胆固醇血症等状况是重大的公共卫生挑战。本研究调查了口腔健康指标(包括牙龈出血、活动性龋齿、牙齿松动和牙齿缺失)对匈牙利这些疾病流行率的影响,同时考虑了社会经济、人口统计学和生活方式因素。

材料与方法

本分析基于 2019 年匈牙利欧洲健康访谈调查的数据,共有 5603 名参与者。数据来源于 2023 年 9 月至 11 月期间由德布勒森大学健康信息学系维护的记录。变量选择采用弹性网络正则化和 k 折交叉验证,为加权多项逻辑回归模型生成高性能预测器。敏感性分析验证了研究结果的有效性。

结果

口腔健康不良与慢性心脏疾病之间存在显著关联。多颗牙齿拔除增加了高血压风险(OR=1.67,95%CI:[1.01-2.77]);镶牙的 OR 为 1.45 [1.20-1.75]。牙龈出血与更高的心血管疾病(OR=1.69 [1.30-2.21])和高胆固醇血症风险(OR=1.40 [1.09-1.81])相关。

结论

改善口腔健康可能降低心脏疾病的风险。这突显了口腔健康在多学科疾病管理中的作用。

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