普瑞巴林诱发的大疱性类天疱疮：一例罕见的药物引发的自身免疫性皮肤病病例报告

Pregabalin-Induced Bullous Pemphigoid: A Case Report of a Rare Drug-Triggered Autoimmune Skin Disorder.

作者信息

Tovar Rachel, Jones Daniel T, Srinivasmurthy Ramaditya, Pandit Meghana, Ho Liawaty

机构信息

Internal Medicine, Touro University Nevada College of Osteopathic Medicine, Henderson, USA.

Oncology, Comprehensive Cancer Centers of Nevada, Las Vegas, USA.

出版信息

Cureus. 2024 Sep 18;16(9):e69649. doi: 10.7759/cureus.69649. eCollection 2024 Sep.

DOI:10.7759/cureus.69649

PMID:39296925

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11409904/

Abstract

Bullous pemphigoid (BP) is a common autoimmune blistering disorder primarily affecting the elderly, characterized by intense pruritus and tense bullae on the skin. We report the case of a 75-year-old female with a history of breast cancer who developed BP on both feet following the initiation of pregabalin for pain management. Histopathological examination confirmed BP, and symptoms improved with topical corticosteroid treatment and discontinuation of pregabalin. This case highlights the potential of pregabalin to induce BP and underscores the importance of recognizing medication-induced bullous diseases for prompt diagnosis and management.

摘要

大疱性类天疱疮（BP）是一种常见的自身免疫性水疱病，主要影响老年人，其特征为皮肤剧烈瘙痒和紧张性大疱。我们报告一例75岁女性乳腺癌患者，在开始使用普瑞巴林进行疼痛管理后双足出现BP。组织病理学检查确诊为BP，局部使用糖皮质激素治疗并停用普瑞巴林后症状改善。该病例突出了普瑞巴林诱发BP的可能性，并强调了认识药物性大疱病以进行及时诊断和管理的重要性。