Roweth Harvey G
Hematology Division, Brigham and Women's Hospital, Boston, Massachusetts.
Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Semin Thromb Hemost. 2024 Apr;50(3):455-461. doi: 10.1055/s-0043-1776005. Epub 2023 Oct 13.
Alongside their conventional roles in thrombosis and hemostasis, platelets have long been associated with nonhemostatic pathologies, including tumor cell metastasis. Numerous mechanistic studies have since demonstrated that the direct binding of platelets to intravascular tumor cells promotes key hallmarks of metastasis, including survival in circulation and tumor cell arrest at secondary sites. However, platelets also interact with nonmalignant cells that make up the stromal and immune compartments within both primary and metastatic tumors. This review will first provide a brief historical perspective on platelet contributions to metastatic disease before discussing the emerging roles that platelets play in creating microenvironments that likely support successful tumor cell metastasis.
除了在血栓形成和止血方面的传统作用外，血小板长期以来一直与非止血性病理状况相关，包括肿瘤细胞转移。此后的大量机制研究表明，血小板与血管内肿瘤细胞的直接结合促进了转移的关键特征，包括在循环中的存活以及肿瘤细胞在继发部位的停滞。然而，血小板也与构成原发性和转移性肿瘤内基质和免疫区室的非恶性细胞相互作用。在讨论血小板在创造可能支持肿瘤细胞成功转移的微环境中所起的新作用之前，本综述将首先简要介绍血小板对转移性疾病贡献的历史观点。
