Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Heart Center, Turku University Hospital and University of Turku, Turku, Finland.
Cancer Epidemiol Biomarkers Prev. 2024 Jul 1;33(7):923-932. doi: 10.1158/1055-9965.EPI-23-1000.
Lifestyle factors may affect cancer risk. This study aimed to identify whether the American Heart Association ideal cardiovascular health (ICH) score and its individual variables in youth are associated with subsequent cancer incidence.
This study comprised participants of the Cardiovascular Risk in Young Finns Study free of cancer at the analysis baseline in 1986 (n = 1,873). The baseline age was 12 to 24 years, and the follow-up occurred between 1986 and 2018.
Among 1,873 participants (mean age 17.3 ± 4.1 years; 53.4% females at baseline), 72 incident cancer cases occurred during the follow-up (mean follow-up time 31.4 ± 3.4 years). Baseline ICH score was not associated with future cancer risk (HR, 0.96; 95% confidence interval, 0.78-1.12 per 1-point increment). Of individual ICH score variables, ideal physical activity (PA) was inversely associated with cancer incidence [age- and sex-adjusted HR, 0.45 (0.23-0.88) per 1-category change (nonideal/ideal)] and remained significant in the multivariable-adjusted model, including body mass index, smoking, diet, and socioeconomic status. A continuous PA index at ages 9 to 24 years and moderate-to-vigorous PA in youth were also related to decreased cancer incidence (P < 0.05). Body mass index, smoking, diet, total cholesterol, glucose, and blood pressure were not related to cancer risk. Of the dietary components, meat consumption was associated with cancer incidence (P = 0.023).
These findings indicate that higher PA levels in youth are associated with a reduced subsequent cancer incidence, whereas the American Heart Association's ICH score in youth does not.
This finding supports efforts to promote a healthy lifestyle and encourages PA during childhood, yielding a subsequent healthier life.
生活方式因素可能会影响癌症风险。本研究旨在确定美国心脏协会的理想心血管健康（ICH）评分及其在年轻人中的个体变量是否与随后的癌症发病率有关。
本研究包括在分析基线时（1986 年）无癌症的心血管风险在年轻芬兰人中的参与者（n = 1873）。基线年龄为 12 至 24 岁，随访时间为 1986 年至 2018 年。
在 1873 名参与者中（平均年龄 17.3 ± 4.1 岁；基线时 53.4%为女性），随访期间发生了 72 例癌症病例（平均随访时间为 31.4 ± 3.4 年）。基线 ICH 评分与未来的癌症风险无关（HR，0.96；95%置信区间，每增加 1 分 0.78-1.12）。在个别 ICH 评分变量中，理想的体力活动（PA）与癌症发病率呈负相关[年龄和性别调整后的 HR，每改变 1 个类别（非理想/理想）为 0.45（0.23-0.88）]，并且在包括体重指数、吸烟、饮食和社会经济状况在内的多变量调整模型中仍然显著。9 至 24 岁时的 PA 指数连续变化和年轻人的中度至剧烈 PA 也与癌症发病率降低有关（P < 0.05）。体重指数、吸烟、饮食、总胆固醇、血糖和血压与癌症风险无关。在饮食成分中，肉类消费与癌症发病率相关（P = 0.023）。
这些发现表明，年轻人中更高的 PA 水平与随后的癌症发病率降低有关，而年轻人的美国心脏协会 ICH 评分则不然。
这一发现支持促进健康生活方式的努力，并鼓励儿童时期进行 PA，从而带来更健康的生活。
