Chen Yen-Fu, Chang Yi-Chih, Li Wen-Cheng, Lin Po-Ya, Chen Yi-Hsuan, Chen Yi-Chuan, Yang Ting-An, Chen Jo-Hsuan
Chang-Gung Memorial Hospital at Linkou Department of Family Medicine Taoyuan Taiwan Department of Family Medicine, Chang-Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Xiamen Chang-Gung Hospital Department of Cardiology Xiamen China Department of Cardiology, Xiamen Chang-Gung Hospital, Xiamen, China.
Arch Endocrinol Metab. 2025 Aug 20;69(4):e250115. doi: 10.20945/2359-4292-2025-0115.
This study determined the optimal cutoff point for the triglyceride-glucose (TyG) index for predicting subclinical atherosclerosis (SA). Subjects and.
Overall, 10,039 participants (5,598 men and 4,441 women) aged > 18 years were recruited from Xiamen Chang Gung Hospital. Demographic information was provided, and the TyG index was calculated. The TyG index was categorized into quartiles, and SA was assessed by measuring brachial-ankle pulse wave velocity (baPWV). The cutoff point for the TyG index was determined via receiver operating characteristic (ROC) curve analysis.
SA incidence increased with increasing TyG index in both men (from 5.929% in Group I to 10.579% in Group IV; P < 0.001) and women (from 2.074% in Group I to 14.955% in Group IV; P < 0.001). Multivariate linear regression analysis revealed that a higher TyG index was associated with an elevated risk of SA in men (odds ratio [OR] 4.028, 95% confidence interval [CI] 2.811-5.711) and women (OR 2.599, 95% CI 1.86-5.543). ROC curve analysis revealed that the area under the curve was 0.572 (95% CI = 0.541-0.602; P < 0.001) for men and 0.694 (95% CI = 0.668-0.721; P < 0.001) for women. The optimal TyG index cutoff points for predicting subclinical atherosclerosis were 8.961 for men (sensitivity, 46.5%; specificity, 67.9%) and 8.254 for women (sensitivity, 79.7%; specificity, 49.9%).
The TyG index is a composite indicator of dyslipidemia and hyperglycemia. In clinical practice, women with TyG index values above the cutoff should be further evaluated for the underlying pulse wave velocity.
本研究确定用于预测亚临床动脉粥样硬化（SA）的甘油三酯-葡萄糖（TyG）指数的最佳截断点。对象与方法：共纳入厦门长庚医院10,039名年龄大于18岁的参与者（5,598名男性和4,441名女性）。收集人口统计学信息并计算TyG指数。将TyG指数分为四分位数，并通过测量臂踝脉搏波速度（baPWV）评估SA。通过受试者工作特征（ROC）曲线分析确定TyG指数的截断点。结果：男性（从第一组的5.929%增至第四组的10.579%；P<(0.001)）和女性（从第一组的2.074%增至第四组的14.955%；P<(0.001)）的SA发生率均随TyG指数升高而增加。多因素线性回归分析显示，较高的TyG指数与男性（比值比[OR]4.028，95%置信区间[CI]2.81-5.711）和女性（OR 2.599，95%CI 1.86-5.543）的SA风险升高相关。ROC曲线分析显示，男性曲线下面积为0.572（95%CI = 0.541-0.602；P<(0.001)），女性为0.694（95%CI = 0.668-0.721；P<(0.001)）。预测亚临床动脉粥样硬化的最佳TyG指数截断点，男性为8.961（敏感性46.5%，特异性67.9%），女性为8.254（敏感性79.7%，特异性49.9%）。结论：TyG指数是血脂异常和高血糖的综合指标。在临床实践中，TyG指数值高于截断点的女性应进一步评估潜在的脉搏波速度。
