Manibalan Kesavan, Arul Ponnusamy, Wu Hsin-Jay, Huang Sheng-Tung, Mani Veerappan
Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Institute of Biochemical and Biomedical Engineering, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan (ROC).
ACS Meas Sci Au. 2024 Jan 18;4(2):163-183. doi: 10.1021/acsmeasuresciau.3c00057. eCollection 2024 Apr 17.
The development of artificial receptors has great significance in measurement science and technology. The need for a robust version of natural receptors is getting increased attention because the cost of natural receptors is still high along with storage difficulties. Aptamers, imprinted polymers, and nanozymes are some of the matured artificial receptors in analytical chemistry. Recently, a new direction has been discovered by organic chemists, who can synthesize robust, activity-based, self-immolative organic molecules that have artificial receptor properties for the targeted analytes. Specifically designed trigger moieties implant selectivity and sensitivity. These latent electrochemical redox substrates are highly stable, mass-producible, inexpensive, and eco-friendly. Combining redox substrates with the merits of electrochemical techniques is a good opportunity to establish a new direction in artificial receptors. This Review provides an overview of electrochemical redox substrate design, anatomy, benefits, and biosensing potential. A proper understanding of can lead to the development of a library of novel self-immolative redox molecules that would have huge implications for measurement science and technology.
人工受体的发展在测量科学与技术中具有重大意义。由于天然受体成本高昂且储存困难，对其强大版本的需求日益受到关注。适配体、印迹聚合物和纳米酶是分析化学中一些成熟的人工受体。最近，有机化学家发现了一个新方向，他们能够合成具有针对目标分析物的人工受体特性的强大的、基于活性的自牺牲有机分子。经过特殊设计的触发部分赋予了选择性和灵敏度。这些潜在的电化学氧化还原底物高度稳定、可大规模生产、价格低廉且环保。将氧化还原底物与电化学技术的优点相结合，是在人工受体领域开辟新方向的良好契机。本综述概述了电化学氧化还原底物的设计、剖析、优点及生物传感潜力。对其的正确理解能够促成新型自牺牲氧化还原分子库的开发，这将对测量科学与技术产生巨大影响。
