Thalir Sree, Celshia Susai Sherin, Selvamani Muthamizh, Suresh Vasugi, Sethuraman Sathya, Ramalingam Karthikeyan
Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Medical Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 Mar 21;16(3):e56665. doi: 10.7759/cureus.56665. eCollection 2024 Mar.
The pressing need for precise, quick, and affordable detection of diverse biomolecules has led to notable developments in the realm of biosensors. Quercetin, a biomolecule rich in flavonoids predominantly found in our diet, is sensed by the electrochemical method. The electrochemical properties show remarkable improvement when MnO (MO) is doped with cobalt (Co). Aim: This study aimed to investigate the biomolecule sensing of quercetin using Co-doped MO by electrochemical method. Materials and methods: Co-doped MO nanospheres were prepared by hydrothermal method. The crystal structure of the synthesized material was evaluated by using X-ray diffraction analysis. The sample morphology was assessed by using field emission scanning electron microscopy (FE-SEM) techniques. The cyclic voltammetry technique was used for the detection of quercetin biomolecules. Results: The synthesized Co-doped MO appeared to be spherical in morphology in FE-SEM. Energy-dispersive X-ray spectroscopy showed the only presence of Co, Mn, and O, which confirmed the purity of the sample. The modified electrode sensed the biomolecule with a higher current of 7.35 µA than the bare glassy carbon electrode of 6.1 µA.
The Co-doped MO exhibited enhanced conductivity, reactivity, and electrochemical performance. This tailored approach will help in the optimization of material properties toward specific biomolecule sensing applications.
对精确、快速且经济实惠地检测多种生物分子的迫切需求推动了生物传感器领域的显著发展。槲皮素是一种富含黄酮类化合物的生物分子,主要存在于我们的饮食中,可通过电化学方法进行检测。当MnO(MO)掺杂钴(Co)时,其电化学性能有显著改善。目的:本研究旨在通过电化学方法研究用钴掺杂MO对槲皮素进行生物分子传感。材料和方法:采用水热法制备钴掺杂MO纳米球。通过X射线衍射分析评估合成材料的晶体结构。用场发射扫描电子显微镜(FE-SEM)技术评估样品形态。采用循环伏安法检测槲皮素生物分子。结果:在FE-SEM中,合成的钴掺杂MO呈球形。能量色散X射线光谱显示仅存在Co、Mn和O,这证实了样品的纯度。修饰电极检测生物分子时的电流为7.35 μA,高于裸玻碳电极的6.1 μA。结论:钴掺杂MO表现出增强的导电性、反应性和电化学性能。这种定制方法将有助于针对特定生物分子传感应用优化材料性能。