Wan Shengtong, Liu Xin, Sun Wentao, Lv Bo, Li Chun
Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, Institute of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, People's Republic of China.
Department of Chemical Engineering, Tsinghua University, Beijing, China.
Bioresour Bioprocess. 2023 Apr 30;10(1):30. doi: 10.1186/s40643-023-00647-2.
Currently, microbial manufacturing is widely used in various fields, such as food, medicine and energy, for its advantages of greenness and sustainable development. Process optimization is the committed step enabling the commercialization of microbial manufacturing products. However, the present optimization processes mainly rely on experience or trial-and-error method ignoring the intrinsic connection between cellular physiological requirement and production performance, so in many cases the productivity of microbial manufacturing could not been fully exploited at economically feasible cost. Recently, the rapid development of omics technologies facilitates the comprehensive analysis of microbial metabolism and fermentation performance from multi-levels of molecules, cells and microenvironment. The use of omics technologies makes the process optimization more explicit, boosting microbial manufacturing performance and bringing significant economic benefits and social value. In this paper, the traditional and omics technologies-guided process optimization of microbial manufacturing are systematically reviewed, and the future trend of process optimization is prospected.
目前，微生物制造因其绿色和可持续发展的优势，在食品、医药和能源等各个领域得到广泛应用。工艺优化是实现微生物制造产品商业化的关键步骤。然而，目前的优化过程主要依赖经验或试错法，忽视了细胞生理需求与生产性能之间的内在联系，因此在许多情况下，微生物制造的生产力无法以经济可行的成本得到充分利用。近年来，组学技术的快速发展有助于从分子、细胞和微环境等多层次对微生物代谢和发酵性能进行全面分析。组学技术的应用使工艺优化更加明确，提高了微生物制造性能，带来了显著的经济效益和社会价值。本文系统综述了传统的和组学技术指导的微生物制造工艺优化，并展望了工艺优化的未来趋势。
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