El-Sayed Sayed E, Abdelaziz Neveen A, Alshahrani Mohammad Y, El-Housseiny Ghadir S, Aboshanab Khaled M
Department of Microbiology and Immunology, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Future Sci OA. 2024 Dec;10(1):2430452. doi: 10.1080/20565623.2024.2430452. Epub 2024 Nov 26.
is a Gram-negative, rod-shaped bacterium that is common in the environment and has been reported to have various bioactive metabolites of industrial potential applications, including antifungal, antibacterial, antimycobacterial, antiparasitic, anticancer, antioxidant activities. In this review, we highlighted and discussed the respective metabolites, pointing out their chemical diversities, purification, current challenges, and future directions. has an industrial role in biodegradation, biosurfactants, and different enzyme production. In this review, the up-to-date various Response Surface Methodology methods (RSM) that can be employed for statistical optimization of the bioactive secondary metabolites have been discussed and highlighted, pointing out the optimal use of each method, current challenges, and future directions.
是一种革兰氏阴性杆菌，呈杆状，在环境中很常见，据报道具有多种具有工业潜在应用的生物活性代谢物，包括抗真菌、抗菌、抗分枝杆菌、抗寄生虫、抗癌、抗氧化活性。在本综述中，我们重点介绍并讨论了各自的代谢物，指出了它们的化学多样性、纯化、当前挑战和未来方向。在生物降解、生物表面活性剂和不同酶的生产中具有工业作用。在本综述中，讨论并重点介绍了可用于生物活性次生代谢物统计优化的最新各种响应面法（RSM），指出了每种方法的最佳用途、当前挑战和未来方向。
