Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bengaluru, India.
Indian J Ophthalmol. 2024 May 1;72(5):728-734. doi: 10.4103/IJO.IJO_1557_23. Epub 2024 Apr 22.
To study the choroidal thickness (CT) and central macular thickness (CMT) in post-fever retinitis (PFR) and their correlation with visual acuity and treatment.
A retrospective, observational study of patients presenting with PFR from 2013 to 2021 and with spectral domain optical coherence tomography (SD-OCT) (Heidelberg®, SpectralisTM, Heidelberg, Germany) images were included. The CT and CMT were measured at presentation and at the final visit. The CT was measured subfoveally and at points 2000 µm superior, inferior, medial, and lateral from the fovea using the caliper tool.
Seventy-nine eyes of 65 patients were included for this study. The mean age was 39.03 (±16.00) years with female preponderance of 53.84% (n = 35). Mean follow-up duration was 30 days. Mean CT at presentation and at follow-up was 254.12 µm and 241.51 µm, respectively. CT was decreased in majority of the eyes 67.1% (n = 53) from their baseline value. Mean CMTs at presentation and final visit were 454.8 µm and 223.7 µm, respectively. Best corrected visual acuity had a positive correlation with CMT (r = 0.340; P = 0.002) and negligible correlation with CT. A significant decrease in the mean CT was noted in patients who received doxycycline either alone or in combination with a steroid as compared to those who did not receive any treatment (P < 0.001). The significance of which is unknown presently.
CMT has a greater role in determining the final visual outcome than CT. CT can be reduced post-treatment with no effect on vision.
研究发热后视网膜病变（PFR）的脉络膜厚度（CT）和中心黄斑厚度（CMT）及其与视力和治疗的关系。
回顾性观察 2013 年至 2021 年期间出现 PFR 并进行谱域光相干断层扫描（SD-OCT）（海德堡，SpectralisTM，德国海德堡）图像检查的患者。在就诊时和最后一次就诊时测量 CT 和 CMT。使用卡尺工具在黄斑下和距黄斑 2000µm 上方、下方、内侧和外侧测量 CT。
本研究纳入了 65 例 79 只眼。平均年龄为 39.03（±16.00）岁，女性占 53.84%（n = 35）。平均随访时间为 30 天。就诊时和随访时的平均 CT 分别为 254.12µm 和 241.51µm。基线值的 67.1%（n = 53）的眼睛 CT 降低。就诊时和最终就诊时的平均 CMT 分别为 454.8µm 和 223.7µm。最佳矫正视力与 CMT 呈正相关（r = 0.340；P = 0.002），与 CT 呈弱相关。与未接受任何治疗的患者相比，单独或联合使用强力霉素治疗的患者 CT 平均值显著降低（P < 0.001）。目前尚不清楚这一结果的意义。
CMT 在确定最终视力结果方面比 CT 更重要。治疗后 CT 可减少，但对视力无影响。
