Cristina da Silva Ádria, de Campos Medeiros Jessica, Pereira Monica Corso
School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Department of Internal Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Pulm Med. 2024 Apr 15;2024:3446536. doi: 10.1155/2024/3446536. eCollection 2024.
The denomination of noncystic fibrosis bronchiectasis (NCFB) includes several causes, and differences may be expected between the patient subgroups regarding age, comorbidities, and clinical and functional evolution. This study sought to identify the main causes of NCFB in a cohort of stable adult patients and to investigate whether such conditions would be different in their clinical, functional, and quality of life aspects.
Between 2017 and 2019, all active patients with NCFB were prospectively evaluated searching for clinical data, past medical history, dyspnea severity grading, quality of life data, microbiological profile, and lung function (spirometry and six-minute walk test).
There was a female predominance; mean age was 54.7 years. Causes were identified in 82% of the patients, the most frequent being postinfections ( = 39), ciliary dyskinesia (CD) ( = 32), and chronic obstructive pulmonary disease (COPD) ( = 29). COPD patients were older, more often smokers (or former smokers) and with more comorbidities; they also had worse lung function (spirometry and oxygenation) and showed worse performance in the six-minute walk test (6MWT) (walked distance and exercise-induced hypoxemia). Considering the degree of dyspnea, in the more symptomatic group, patients had higher scores in the three domains and total score in SGRQ, besides having more exacerbations and more patients in home oxygen therapy.
Causes most identified were postinfections, CD, and COPD. Patients with COPD are older and have worse pulmonary function and more comorbidities. The most symptomatic patients are clinically and functionally more severe, besides having worse quality of life.
非囊性纤维化支气管扩张（NCFB）的命名包含多种病因，预计患者亚组在年龄、合并症以及临床和功能演变方面存在差异。本研究旨在确定一组稳定成年患者中NCFB的主要病因，并调查这些情况在临床、功能和生活质量方面是否存在差异。
在2017年至2019年期间，对所有活动性NCFB患者进行前瞻性评估，收集临床数据、既往病史、呼吸困难严重程度分级、生活质量数据、微生物学特征以及肺功能（肺量计和六分钟步行试验）。
女性占多数；平均年龄为54.7岁。82%的患者确定了病因，最常见的是感染后（=39）、纤毛运动障碍（CD）（=32）和慢性阻塞性肺疾病（COPD）（=29）。COPD患者年龄较大，更常为吸烟者（或既往吸烟者）且合并症更多；他们的肺功能（肺量计和氧合）也较差，在六分钟步行试验（6MWT）中的表现更差（步行距离和运动诱发的低氧血症）。考虑到呼吸困难程度，在症状更明显的组中，患者在SGRQ的三个领域和总分中的得分更高，此外加重发作更多，接受家庭氧疗的患者更多。
最常见的病因是感染后、CD和COPD。COPD患者年龄较大，肺功能较差且合并症更多。症状最明显的患者在临床和功能上更严重，生活质量也更差。
