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免疫疾病与偏头痛之间的遗传因果关系：一项孟德尔随机化研究。

Genetic causal relationship between immune diseases and migraine: a Mendelian randomization study.

作者信息

Li Guanglu, Duan Shaojie, Zheng Tao, Zhu Tiantian, Qu Baoquan, Liu Lei, Liu Zunjing

机构信息

Graduate School of Beijing University of Chinese Medicine, Beijing, China.

Department of Neurology, China-Japan Friendship Hospital, Beijing, China.

出版信息

Front Immunol. 2024 Apr 8;15:1376698. doi: 10.3389/fimmu.2024.1376698. eCollection 2024.

DOI:10.3389/fimmu.2024.1376698
PMID:38650934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11033421/
Abstract

BACKGROUND

Migraine has an increased prevalence in several immune disorders, but genetic cause-effect relationships remain unclear. Mendelian randomization (MR) was used in this study to explore whether immune diseases are causally associated with migraine and its subtypes.

METHODS

We conducted a two-sample bidirectional multivariate Mendelian randomization study. Single-nucleotide polymorphisms (SNP) for six immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), allergic rhinitis (AR), asthma and psoriasis, were used as genetic instrumental variables. Summary statistics for migraine were obtained from 3 databases: the International Headache Genetics Consortium (IHGC), UK Biobank, and FinnGen study. MR analyses were performed per outcome database for each exposure and subsequently meta-analyzed. Reverse MR analysis was performed to determine whether migraine were risk factors for immune diseases. In addition, we conducted a genetic correlation to identify shared genetic variants for these two associations.

RESULTS

No significant causal relationship was found between immune diseases and migraine and its subtypes. These results were robust with a series of sensitivity analyses. Using the linkage disequilibrium score regression method (LDSC), we detected no genetic correlation between migraine and immune diseases.

CONCLUSION

The evidence from our study does not support a causal relationship between immune diseases and migraine. The mechanisms underlying the frequent comorbidity of migraine and several immune diseases need to be further elucidated.

摘要

背景

偏头痛在几种免疫疾病中的患病率有所增加，但遗传因果关系仍不明确。本研究采用孟德尔随机化（MR）方法探讨免疫疾病与偏头痛及其亚型之间是否存在因果关系。

方法

我们进行了一项两样本双向多变量孟德尔随机化研究。将六种免疫疾病的单核苷酸多态性（SNP），包括类风湿性关节炎（RA）、系统性红斑狼疮（SLE）、1型糖尿病（T1D）、过敏性鼻炎（AR）、哮喘和银屑病，用作遗传工具变量。偏头痛的汇总统计数据来自3个数据库：国际头痛遗传学联盟（IHGC）、英国生物银行和芬兰基因研究。针对每种暴露因素，在每个结局数据库中进行MR分析，随后进行荟萃分析。进行反向MR分析以确定偏头痛是否为免疫疾病的危险因素。此外，我们进行了遗传相关性分析以确定这两种关联的共享遗传变异。

结果

未发现免疫疾病与偏头痛及其亚型之间存在显著因果关系。这些结果在一系列敏感性分析中具有稳健性。使用连锁不平衡评分回归方法（LDSC），我们未检测到偏头痛与免疫疾病之间存在遗传相关性。

结论

我们的研究证据不支持免疫疾病与偏头痛之间存在因果关系。偏头痛与几种免疫疾病频繁共病的潜在机制需要进一步阐明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/4f589480ef71/fimmu-15-1376698-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/855f3392e1f2/fimmu-15-1376698-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/1819af1b1515/fimmu-15-1376698-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/6c148505c021/fimmu-15-1376698-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/f05b5528f86e/fimmu-15-1376698-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/4f589480ef71/fimmu-15-1376698-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/855f3392e1f2/fimmu-15-1376698-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/1819af1b1515/fimmu-15-1376698-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/6c148505c021/fimmu-15-1376698-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/f05b5528f86e/fimmu-15-1376698-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe10/11033421/4f589480ef71/fimmu-15-1376698-g005.jpg

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J Headache Pain. 2023 Sep 18;24(1):129. doi: 10.1186/s10194-023-01662-6.
2
Migraine, Allergy, and Histamine: Is There a Link?偏头痛、过敏与组胺：它们之间有关联吗？
J Clin Med. 2023 May 19;12(10):3566. doi: 10.3390/jcm12103566.
3
Genetics of migraine: where are we now?偏头痛的遗传学研究进展：我们现在处于什么阶段？
J Headache Pain. 2023 Feb 20;24(1):12. doi: 10.1186/s10194-023-01547-8.
4
Association of autoimmune diseases with Alzheimer's disease: A mendelian randomization study.自身免疫性疾病与阿尔茨海默病的关联：一项孟德尔随机化研究。
J Psychiatr Res. 2022 Nov;155:550-558. doi: 10.1016/j.jpsychires.2022.09.052. Epub 2022 Sep 29.
5
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.对 102084 例偏头痛病例的全基因组分析确定了 123 个风险基因座和亚型特异性风险等位基因。
Nat Genet. 2022 Feb;54(2):152-160. doi: 10.1038/s41588-021-00990-0. Epub 2022 Feb 3.
6
Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research.神经源性炎症：偏头痛的参与者及转化研究的最新进展
Biomedicines. 2021 Dec 30;10(1):76. doi: 10.3390/biomedicines10010076.
7
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8
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