Department of Pharmaceutical Chemistry, S.M.B.T. College of Pharmacy, Affiliated to Savitribai Phule Pune University, Dhamangaon, Nashik, M.S. India-422403.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2023 Dec 5;39:e20230001. doi: 10.62958/j.cjap.2023.001.
Silver nanoclusters (AgNCs) have emerged as versatile nanomaterials with immense potential in theranostic applications, combining therapeutic and diagnostic functions in a single platform. This review provides a comprehensive overview of recent advancements in the synthesis, characterization, and utilization of AgNCs for theranostics. The synthesis of AgNCs has witnessed significant progress, with numerous strategies such as chemical reduction, green synthesis, and templated approaches being employed to control size, shape, and stability. Their unique optical properties, including strong fluorescence and surface-enhanced Raman scattering (SERS) signals, make AgNCs ideal candidates for bioimaging and diagnostic purposes. Additionally, the surface chemistry of AgNCs allows for facile functionalization with targeting ligands and therapeutic agents, enhancing their specificity and efficacy. In the realm of diagnostics, AgNCs have been employed for various imaging modalities, including fluorescence imaging, photoacoustic imaging, and SERS-based sensing. Their excellent photostability and biocompatibility make them suitable for in vitro and in vivo imaging applications, enabling the real-time monitoring of disease progression and treatment response.
银纳米簇（AgNCs）作为一种多功能纳米材料，在治疗诊断应用中具有巨大的潜力，在单个平台上结合了治疗和诊断功能。本综述全面概述了 AgNCs 在治疗诊断方面的合成、表征和应用的最新进展。AgNCs 的合成取得了重大进展，采用了多种策略，如化学还原法、绿色合成法和模板法，以控制其尺寸、形状和稳定性。AgNCs 具有独特的光学性质，包括强荧光和表面增强拉曼散射（SERS）信号，使其成为生物成像和诊断目的的理想候选物。此外，AgNCs 的表面化学可方便地进行靶向配体和治疗剂的功能化，增强其特异性和疗效。在诊断领域，AgNCs 已被用于各种成像模式，包括荧光成像、光声成像和基于 SERS 的传感。AgNCs 的优异光稳定性和生物相容性使其适用于体外和体内成像应用，能够实时监测疾病进展和治疗反应。
