Yamada Kaoru, Iwatsubo Takeshi
Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Cell Mol Life Sci. 2024 Apr 23;81(1):192. doi: 10.1007/s00018-024-05225-z.
Alzheimer's disease (AD) is pathologically characterized by the abnormal accumulation of Aβ and tau proteins. There has long been a keen interest among researchers in understanding how Aβ and tau are ultimately cleared in the brain. The discovery of this glymphatic system introduced a novel perspective on protein clearance and it gained recognition as one of the major brain clearance pathways for clearing these pathogenic proteins in AD. This finding has sparked interest in exploring the potential contribution of the glymphatic/meningeal lymphatic system in AD. Furthermore, there is a growing emphasis and discussion regarding the possibility that activating the glymphatic/meningeal lymphatic system could serve as a novel therapeutic strategy against AD.
Given this current research trend, the primary focus of this comprehensive review is to highlight the role of the glymphatic/meningeal lymphatic system in the pathogenesis of AD. The discussion will encompass future research directions and prospects for treatment in relation to the glymphatic/meningeal lymphatic system.
阿尔茨海默病（AD）的病理特征是β-淀粉样蛋白（Aβ）和tau蛋白异常积聚。长期以来，研究人员一直热衷于了解Aβ和tau蛋白最终如何在大脑中清除。淋巴系统的发现为蛋白质清除引入了一个新的视角，并被认为是清除AD中这些致病蛋白的主要脑清除途径之一。这一发现引发了人们对探索淋巴/脑膜淋巴系统在AD中的潜在作用的兴趣。此外，关于激活淋巴/脑膜淋巴系统可能成为对抗AD的新治疗策略的可能性，人们的重视和讨论也日益增加。
鉴于当前的研究趋势，这篇综述的主要重点是强调淋巴/脑膜淋巴系统在AD发病机制中的作用。讨论将涵盖与淋巴/脑膜淋巴系统相关的未来研究方向和治疗前景。
