Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA; Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, USA.
Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA.
Brain Behav Immun. 2018 Oct;73:34-40. doi: 10.1016/j.bbi.2018.07.020. Epub 2018 Jul 25.
Recent reports describing lymphatic vasculature in the meninges have challenged the traditional understanding of interstitial solute clearance from the central nervous system, although the significance of this finding in human neurological disease remains unclear. To begin to define the role of meningeal lymphatic function in the clearance of interstitial amyloid beta (Aβ), and the contribution that its failure may make to the development of Alzheimer's disease (AD), we examined meningeal tissue from a case series including AD and control subjects by confocal microscopy. Our findings confirm the presence of lymphatic vasculature in the human meninges and indicate that, unlike perivascular efflux pathways in the brain parenchyma in subjects with AD, Aβ is not deposited in or around meningeal lymphatic vessels associated with dural sinuses. Our findings demonstrate that while the meningeal lymphatic vasculature may serve as an efflux route for Aβ from the brain and cerebrospinal fluid, Aβ does not deposit in the walls of meningeal lymphatic vessels in the setting of AD.
最近有报道描述了脑膜中的淋巴管，这对传统的中枢神经系统间质溶质清除的理解提出了挑战，尽管这一发现对人类神经疾病的意义尚不清楚。为了开始确定脑膜淋巴管功能在清除间质β淀粉样蛋白（Aβ）中的作用，以及其功能衰竭可能对阿尔茨海默病（AD）发展的贡献，我们通过共聚焦显微镜检查了包括 AD 和对照受试者的病例系列的脑膜组织。我们的发现证实了人类脑膜中存在淋巴管，并表明与 AD 患者脑实质中的血管周围流出途径不同，Aβ不会沉积在与硬脑膜窦相关的脑膜淋巴管内或周围。我们的研究结果表明，虽然脑膜淋巴管系统可能是 Aβ从大脑和脑脊液中排出的流出途径，但在 AD 中，Aβ不会沉积在脑膜淋巴管的壁上。
