Pritchett P M, Jay W M, Aziz M Z, Green K
Acta Ophthalmol (Copenh). 1985 Oct;63(5):519-24. doi: 10.1111/j.1755-3768.1985.tb05238.x.
Naproxen effects on the ocular inflammatory response following extracapsular lens extraction were studied in rabbits. Twelve hours before surgery, rabbits were given 20 mg of a 5 mg/ml naproxen suspension by gavage. A maintenance dose of 10 mg naproxen 3 times per day was started on the day of lensectomy and continued throughout the entire observation period. Phakic and aphakic control rabbits received no drug suspension. Central corneal thickness and intraocular pressure measurements were determined pre-operatively, at 4 and 24 h post-operatively and every 24 h thereafter. Four groups of rabbits, sacrificed at 24, 48, 72, and 168 h after lensectomy, had anterior chamber paracentesis performed for PMN (polymorphonuclear leucocyte) counts and determination of protein content. A 5th group had both paracentesis and iris-ciliary body excision for PGE2 assay at 24 h. No parameter was significantly altered by the naproxen regimen compared to untreated rabbits.
在兔子身上研究了萘普生对囊外晶状体摘除术后眼部炎症反应的影响。手术前12小时，通过灌胃给兔子服用20毫克5毫克/毫升的萘普生悬浮液。在晶状体切除当天开始每天3次给予10毫克萘普生的维持剂量，并在整个观察期内持续给药。有晶状体和无晶状体对照兔子未接受药物悬浮液。在术前、术后4小时和24小时以及此后每24小时测量中央角膜厚度和眼压。四组兔子在晶状体切除术后24、48、72和168小时处死，进行前房穿刺以计数多形核白细胞（PMN）并测定蛋白质含量。第五组在24小时进行前房穿刺和虹膜睫状体切除以检测前列腺素E2（PGE2）。与未治疗的兔子相比，萘普生治疗方案未显著改变任何参数。
