Dravid Ashish, Sung Wen-Shan, Song Jeeuk, Dubey Arvind, Eftekhar Behzad
Department of Neurosurgery, Nepean Hospital, The University of Sydney, Sydney, Australia.
Department of Neurosurgery, Royal Hobart Hospital, Hobart, Australia.
Emerg Med Int. 2024 Apr 16;2024:6631990. doi: 10.1155/2024/6631990. eCollection 2024.
Knowledge about biological rhythms of diseases may not only help in understanding the pathophysiology of diseases but can also help health service policy makers and emergency department directors to allocate resources efficiently. Aneurysmal subarachnoid haemorrhage (SAH) has high rates of morbidity and mortality. The incidence of SAH has been attributed to patient-related factors such as characteristics of aneurysms, smoking, and hypertension. There are studies showing that the incidence of aneurysmal SAH appears to behave in periodic fashions over long time periods. However, there are inconsistencies in the literature regarding the impact of chronobiological factors such as circadian, seasonal, and lunar cycle factors on the occurrence of SAH. In this study, we focused on the analysis of a temporal pattern of SAH (infradian rhythms) with a novel approach using circular statistical methods. We aimed to see whether there is a circular pattern for the occurrence of SAH at all and if so, whether it can be related to known temporal patterns based on available literature. Our study did not support the notion that aneurysmal subarachnoid haemorrhages occur on any specific day in a cycle with specific lengths up to 365 days including specific weekdays, full moon, equinoxes, and solstices. Hence, we found no relationship between SAH incidence and timing. Study in larger populations using similar circular statistical methods is suggested.
了解疾病的生物节律不仅有助于理解疾病的病理生理学，还能帮助卫生服务政策制定者和急诊科主任有效分配资源。动脉瘤性蛛网膜下腔出血（SAH）的发病率和死亡率很高。SAH的发病率归因于与患者相关的因素，如动脉瘤的特征、吸烟和高血压。有研究表明，动脉瘤性SAH的发病率在很长一段时间内似乎呈周期性变化。然而，关于昼夜节律、季节和月周期等时间生物学因素对SAH发生的影响，文献中存在不一致之处。在本研究中，我们采用一种新颖的方法，即使用圆形统计方法，重点分析SAH的时间模式（亚日节律）。我们旨在确定SAH的发生是否存在圆形模式，如果存在，它是否可以与现有文献中已知的时间模式相关。我们的研究不支持动脉瘤性蛛网膜下腔出血在长达365天的特定周期内的任何特定日子发生的观点，这些特定日子包括特定工作日、满月、春分和冬至。因此，我们发现SAH发病率与时间之间没有关系。建议使用类似的圆形统计方法在更大的人群中进行研究。
