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非典型慢性髓细胞白血病中8号和9号染色体之间的相互易位。

Reciprocal translocation between chromosomes 8 and 9 in atypical chronic myeloid leukaemia.

作者信息

Oscier D G, Mufti G J, Gardiner A, Hamblin T J

出版信息

J Med Genet. 1985 Oct;22(5):398-401. doi: 10.1136/jmg.22.5.398.

DOI:10.1136/jmg.22.5.398
PMID:3866076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1049488/
Abstract

A balanced translocation t(8;9) (p11;q34) was present in the peripheral blood, bone marrow, and spleen cells of a patient with Ph negative chronic myeloid leukaemia. Subsequent transformation into acute leukaemia was associated with the emergence of trisomy 8 and der(8)(8qter----cen----8p11::9q34----9qter). This is the third reported case of t(8;9) (p11;q34) and raises the question of the role of c-abl in the pathogenesis of this myeloproliferative disorder.

摘要

一名Ph阴性慢性髓性白血病患者的外周血、骨髓和脾细胞中存在平衡易位t(8;9) (p11;q34)。随后向急性白血病的转化与8号染色体三体和der(8)(8qter----cen----8p11::9q34----9qter)的出现有关。这是第三例报道的t(8;9) (p11;q34)病例，并提出了c-abl在这种骨髓增殖性疾病发病机制中的作用问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8f/1049488/7764f5721cc8/jmedgene00097-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8f/1049488/7764f5721cc8/jmedgene00097-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8f/1049488/7764f5721cc8/jmedgene00097-0072-a.jpg

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本文引用的文献

1
Unusual translocation and chronic myelocytic leukemia: "masked" Philadelphia chromosome (Ph 1).异常易位与慢性粒细胞白血病：“隐匿型”费城染色体（Ph1）
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Nature. 1983;306(5940):277-80. doi: 10.1038/306277a0.
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Philadelphia chromosome-negative chronic myelogenous leukemia in a child with t(8;9)(p11 or 12;q34).一名患有t(8;9)(p11或12;q34)的儿童的费城染色体阴性慢性粒细胞白血病
Am J Pediatr Hematol Oncol. 1983 Fall;5(3):265-9.
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Novel reciprocal translocation between chromosomes 8 and 9 found in a patient with myeloproliferative disorder.在一名骨髓增殖性疾病患者中发现了8号和9号染色体之间新的相互易位。
Cancer Genet Cytogenet. 1983 Aug;9(4):391-4. doi: 10.1016/0165-4608(83)90088-2.
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Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia.慢性粒细胞白血病中与易位断点相邻的c-ab1癌基因的定位。
Nature. 1983;306(5940):239-42. doi: 10.1038/306239a0.
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Identification of pure and mixed basophil colonies in culture of human peripheral blood and marrow cells.人外周血和骨髓细胞培养中纯嗜碱性粒细胞集落及混合嗜碱性粒细胞集落的鉴定
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