异常易位与慢性粒细胞白血病：“隐匿型”费城染色体（Ph1）
Unusual translocation and chronic myelocytic leukemia: "masked" Philadelphia chromosome (Ph 1).
作者信息
Lessard M, Duval S, Fritz A
出版信息
Cancer Genet Cytogenet. 1981 Nov;4(3):237-44. doi: 10.1016/0165-4608(81)90017-0.
PMID:6947859
Abstract
An unusual Ph 1 translocation in a woman, 65 years old, with chronic myelocytic leukemia is reported. Cytogenetic analysis performed on 150 mitoses examined with Q-, R-, and C-banding revealed evidence for an unusual translocation involving the insertion of a segment of chromosome #9 into chromosome #22, thus masking the presence of a Ph 1. The anomaly can best be described as 46, XX, ins(22;9) (q11;q22 to 34).
摘要
报告了一名65岁患慢性粒细胞白血病女性的罕见Ph 1易位情况。对150个经Q带、R带和C带检查的有丝分裂细胞进行细胞遗传学分析，发现存在一种罕见易位的证据，即9号染色体的一个片段插入到22号染色体中，从而掩盖了Ph 1的存在。该异常情况最好描述为46, XX, ins(22;9) (q11;q22至34)。
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