Lisker R, Casas L, Mutchinick O, Pérez-Chávez F, Labardini J
Blood. 1980 Nov;56(5):812-4.
We describe two patients with typical myelogenous leukemia, who at the beginning of the disease lacked the Philadelphia chromosome in bone marrow cells, and 90 and 42 days later, respectively, its presence was shown in all cells analyzed from that tissue. These findings are compatible with the possibility that at least occasionally Ph1 occurs secondarily in already leukemic cells. The rapid change form Ph1- to Ph1+ CML in one of the patients (42 days), suggests the possibility that in addition to Ph1+ cells enjoying marked selective advantage, this change is induced simultaneously in multiple bone marrow cells.
我们描述了两名典型的骨髓性白血病患者，他们在疾病初期骨髓细胞中缺乏费城染色体，分别在90天和42天后，该染色体出现在从该组织分析的所有细胞中。这些发现符合至少偶尔费城染色体在已经白血病化的细胞中继发出现的可能性。其中一名患者（42天）从费城染色体阴性慢性粒细胞白血病迅速转变为阳性，这表明除了费城染色体阳性细胞具有明显的选择性优势外，这种变化还可能在多个骨髓细胞中同时发生。
