Department of Oral Pathology, Akhtar Saeed Medical and Dental College, Lahore, Pakistan.
Department of Oral Pathology, Bakhtawar Amin Medical and Dental College, Multan, Pakistan.
JCO Glob Oncol. 2024 Apr;10:e2300408. doi: 10.1200/GO.23.00408.
Human papillomavirus (HPV) is widely recognized as a key contributing factor in cervical and oropharyngeal cancers. However, there has been limited research on the prevalence of concurrent HPV infections in various anatomic regions. This study aimed to investigate the prevalence and specific types of high-risk HPV (HR-HPV) infections in the cervical and oral regions of females in Punjab, Pakistan.
We conducted a cross-sectional study involving women seeking care for general gynecologic issues at the gynecologic Outpatient Department of Lady Wallington Hospital in Lahore. After interviews and clinical examinations, we collected whole-saliva samples and high vaginal swabs from each participant. HR-HPV detection and genotyping were performed using real-time polymerase chain reaction at both the anatomic sites.
In this study, 170 females, averaging 35.36 ± 8.305 years, participated. HR-HPV infection was more prevalent in the cervix (83/170 [48.8%]) than in the oral cavity (19/170 [11.2%]). Concordant HPV infections occurred in 10/170 participants (5.9%). HPV 16 was the most common genotype in cervical and oral locations, at rates of 21.8% and 5.3%, respectively, among concordant HR-HPV types. Socioeconomic status ( = .013), age at first sexual intercourse ( = .015), and history of oral sex ( = .01) were significantly associated with concurrent HR-HPV infection in both regions.
This study suggests that HR-HPV cervical infections may increase the risk of oral transmission, especially during orogenital sexual practices. Thus, it is important to recognize that HPV infections may be linked in both areas. We emphasize the importance of comprehensive cervical and oral examinations and HPV vaccination in young women irrespective of their sexual practices.
人乳头瘤病毒（HPV）被广泛认为是导致宫颈癌和口咽癌的关键因素。然而，对于不同解剖部位同时存在 HPV 感染的流行情况，研究相对较少。本研究旨在调查巴基斯坦旁遮普省女性宫颈和口腔部位高危型 HPV（HR-HPV）感染的流行情况和特定类型。
我们进行了一项横断面研究，纳入在拉合尔 Lady Wallington 医院妇科门诊就诊的因妇科问题寻求治疗的女性。在访谈和临床检查后，我们从每位参与者收集了全唾液样本和阴道高位拭子。在两个解剖部位均使用实时聚合酶链反应进行 HR-HPV 检测和基因分型。
本研究共纳入 170 名女性，平均年龄为 35.36 ± 8.305 岁。HR-HPV 感染在宫颈（83/170 [48.8%]）比口腔（19/170 [11.2%]）更为常见。10/170 名参与者（5.9%）存在 HPV 同时感染。在宫颈和口腔部位，HPV16 是最常见的 HR-HPV 基因型，其比例分别为 21.8%和 5.3%，在同时存在的 HR-HPV 类型中。社会经济地位（ =.013）、初次性行为年龄（ =.015）和口交史（ =.01）与两个部位的同时存在 HR-HPV 感染显著相关。
本研究表明，HR-HPV 宫颈感染可能增加口腔传播的风险，特别是在口交性行为期间。因此，有必要认识到 HPV 感染可能在两个部位都存在关联。我们强调对无论其性行为如何的年轻女性进行全面的宫颈和口腔检查以及 HPV 疫苗接种的重要性。
