Lampkin B C, Peipon J J, Price J K, Bove K E, Srivastava A K, Jones M M
Am J Pediatr Hematol Oncol. 1985 Winter;7(4):346-51.
A 3-hour-old phenotypically normal girl was transferred to Children's Hospital Medical Center because of skin nodules, hepatosplenomegaly, and marked leukocytosis. The predominant cells in the blood, bone marrow, and dermis were monoblasts consistent with congenital leukemia. Known causes of leukemoid reactions were excluded. The infant received two double-volume exchange transfusions but no chemotherapy. As the white blood cell counts decreased, the monocytic cells became more mature, suggesting that the monoblasts had the ability to differentiate. The proliferative capacity of the marrow appeared to be normal as determined by the ability of marrow cells to form colonies in soft agar. Chromosomal analysis of bone marrow blasts including trypsin--Giemsa banding was normal. Three weeks after birth the patient's CBC and physical examination were normal, and the bone marrow was normal by 4 months of age. The patient has remained in remission for over 3 years.
一名出生3小时、表型正常的女婴因皮肤结节、肝脾肿大和明显的白细胞增多症被转诊至儿童医院医疗中心。血液、骨髓和真皮中的主要细胞为原单核细胞，符合先天性白血病。排除了类白血病反应的已知病因。该婴儿接受了两次双倍量换血治疗，但未接受化疗。随着白细胞计数下降，单核细胞变得更加成熟，提示原单核细胞具有分化能力。通过骨髓细胞在软琼脂中形成集落的能力测定，骨髓的增殖能力似乎正常。包括胰蛋白酶-吉姆萨染色在内的骨髓原始细胞染色体分析正常。出生三周后，患者的血常规和体格检查正常，4个月大时骨髓也正常。该患者已缓解超过3年。
