Shitara T, Suetake N, Yugami S, Sotomatu M, Oshima Y, Ijima H, Kuroume T, Nakazawa S
Department of Pediatrics, Gunma University School of Medicine, Japan.
Ann Hematol. 1992 Dec;65(6):274-7. doi: 10.1007/BF01836073.
A case of congenital leukemia with monosomy 7 is reported. Immunological study of the blast cells using monoclonal antibodies was suggestive of both myelomegakaryocytic and T-lymphoblastic leukemia. Chromosomal analysis of the bone marrow cells showed monosomy 7. Chemotherapy was initiated with a combination of adriamycin, cytosine arabinoside, 6-mercaptopurine, and prednisolone. The patient obtained complete remission, which has been maintained for 4 years and 1 month. He receives no chemotherapy now. Our case shows that monosomy 7 in congenital leukemia is rare, but the presence of monosomy 7 in congenital leukemia does not necessarily indicate a poor prognosis.
报告了一例伴有7号染色体单体的先天性白血病病例。使用单克隆抗体对原始细胞进行的免疫学研究提示为骨髓巨核细胞性和T淋巴细胞母细胞性白血病。骨髓细胞的染色体分析显示7号染色体单体。采用阿霉素、阿糖胞苷、6-巯基嘌呤和泼尼松龙联合进行化疗。患者获得完全缓解，已维持4年1个月。他目前未接受化疗。我们的病例表明，先天性白血病中的7号染色体单体很少见，但先天性白血病中存在7号染色体单体并不一定预示预后不良。
