一种复方配方的美白功效，通过紫外线诱导皮肤黑化模型进行检测。
The whitening efficacy of a compound formula examined using an ultraviolet-induced skin melanization model.
机构信息
Center of Cosmetic Evaluation, West China Hospital, Sichuan University, Chengdu, China.
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
出版信息
J Cosmet Dermatol. 2024 Aug;23(8):2750-2756. doi: 10.1111/jocd.16332. Epub 2024 Apr 25.
BACKGROUND
In Eastern culture, a fair complexion is the standard of beauty, leading to appearance-related distress among women with darker skin or facial pigmentation. Women seek whitening cosmetics to enhance their skin tone or correct their pigmentation, but their safety and effectiveness are paramount factors to consider. In this study, we evaluated the safety and whitening effects of a compound formula denoted as TEST comprising astaxanthin, nicotinamide, arbutin, and tranexamic acid.
METHODS
Primary skin irritation and skin-whitening efficacy were examined. Three qualified melanization areas were treated with TEST, 7% ascorbic acid, or a blank. Skin color, the individual type angle (ITA°), and the melanin index (MI) were compared among treatment areas.
RESULTS
TEST did not induce a skin response and exhibited a significantly higher ITA° than the blank, while no significant difference was observed with that of 7% ascorbic acid. Furthermore, the MI of TEST was significantly reduced posttreatment.
CONCLUSIONS
TEST could be integrated into spot-fading and skin-whitening cosmeceuticals or functional cosmetics.
背景
在东方文化中，白皙的肤色是美的标准，这导致肤色较深或面部色素沉着的女性产生与外貌相关的困扰。女性寻求美白化妆品来提亮肤色或纠正肤色，但安全性和有效性是需要考虑的首要因素。在这项研究中，我们评估了一种复合配方 TEST（包含虾青素、烟酰胺、熊果苷和氨甲环酸）的安全性和美白效果。
方法
检测了原发性皮肤刺激和皮肤美白功效。用 TEST、7%抗坏血酸或空白对照处理三个合格的黑色素沉着区域。比较治疗区域的肤色、个体类型角（ITA°）和黑色素指数（MI）。
结果
TEST 不会引起皮肤反应，其 ITA°明显高于空白对照，而与 7%抗坏血酸无显著差异。此外，TEST 的 MI 在治疗后显著降低。
结论
TEST 可以整合到祛斑和美白化妆品或功能性化妆品中。
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