Siligato Rossella, Gembillo Guido, Di Simone Emanuele, Di Maria Alessio, Nicoletti Simone, Scichilone Laura Maria, Capone Matteo, Vinci Francesca Maria, Bondanelli Marta, Malaventura Cristina, Storari Alda, Santoro Domenico, Di Muzio Marco, Dionisi Sara, Fabbian Fabio
Nephrology Unit, University Hospital of Ferrara, 44121 Ferrara, Italy.
Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, 98121 Messina, Italy.
Methods Protoc. 2024 Apr 14;7(2):34. doi: 10.3390/mps7020034.
Financial toxicity (FT) refers to the negative impact of health-care costs on clinical conditions. In general, social determinants of health, especially poverty, socioenvironmental stressors, and psychological factors, are increasingly recognized as important determinants of non-communicable diseases, such as chronic kidney disease (CKD), and their consequences. We aim to investigate the prevalence of FT in patients at different stages of CKD treated in our universal health-care system and from pediatric nephrology, hemodialysis, peritoneal dialysis and renal transplantation clinics. FT will be assessed with the Patient-Reported Outcome for Fighting Financial Toxicity (PROFFIT) score, which was first developed by Italian oncologists. Our local ethics committee has approved the study. Our population sample will answer the sixteen questions of the PROFFIT questionnaire, seven of which are related to the outcome and nine the determinants of FT. Data will be analyzed in the pediatric and adult populations and by group stratification. We are confident that this study will raise awareness among health-care professionals of the high risk of adverse health outcomes in patients who have both kidney disease and high levels of FT. Strategies to reduce FT should be implemented to improve the standard of care for people with kidney disease and lead to truly patient-centered care.
经济毒性（FT）是指医疗费用对临床状况的负面影响。一般来说，健康的社会决定因素，尤其是贫困、社会环境压力源和心理因素，越来越被认为是非传染性疾病（如慢性肾脏病[CKD]）及其后果的重要决定因素。我们旨在调查在我们的全民医疗保健系统中以及在儿科肾脏病、血液透析、腹膜透析和肾移植诊所接受治疗的不同阶段CKD患者中FT的患病率。FT将通过“抗击经济毒性患者报告结局”（PROFFIT）评分进行评估，该评分最初由意大利肿瘤学家制定。我们当地的伦理委员会已批准该研究。我们的人群样本将回答PROFFIT问卷的16个问题，其中7个与结局相关，9个与FT的决定因素相关。数据将在儿科和成人人群中以及按组分层进行分析。我们相信，这项研究将提高医疗保健专业人员对患有肾脏疾病且FT水平高的患者出现不良健康结局的高风险的认识。应实施降低FT的策略，以改善肾病患者的护理标准，并实现真正以患者为中心的护理。
