Pharmacy Department, The Christie NHS Foundation Trust, Manchester, United Kingdom.
National Cancer Institute IRCCS Fondazione G.Pascale, Naples, Italy.
J Cancer Policy. 2023 Dec;38:100440. doi: 10.1016/j.jcpo.2023.100440. Epub 2023 Aug 25.
This study aimed to develop a British version of the Patient Reported Outcomes for Fighting Financial Toxicity of Cancer (PROFFIT): originally designed to measure financial toxicity in cancer for an Italian universal healthcare system. The instrument was carefully evaluated for crosscultural equivalence, face validity and practicality.
A systematic approach to cross-cultural adaptation was used, including forward translation, synthesis, backward translation, consolidation of translations with an expert committee, and cognitive interviews. As part of the cognitive interview process, 18 cancer patients completed a structured interview of 60-90 min in length.
The translated and modified PROFFIT questionnaire demonstrated good psycho-linguistic properties, including high compliance (only one item was revised for clarity), high retrieval from memory, high decision-making processes, and high response processes.
PROFFIT has been found to be functional and adaptable in a new social environment. The tool may be useful for tailoring interventions to address and measure financial hardships within the cancer population, which appear to be a current challenge for public health.
Even in universal healthcare systems, financial toxicity due to the increase in outof-pocket expenses poses a significant problem. The FT phenomenon warrants proper attention in the United Kingdom since it may negatively impact financial well-being, quality of life, psychosocial health, and treatment adherence.
本研究旨在开发英国版患者报告的癌症财务毒性结局（PROFFIT）：最初旨在为意大利全民医疗保健系统测量癌症的财务毒性。该工具经过精心评估，以确保文化间等效性、内容效度和实用性。
采用系统的跨文化适应方法，包括正向翻译、综合、反向翻译、专家委员会对翻译的整合以及认知访谈。在认知访谈过程中，18 名癌症患者完成了 60-90 分钟的结构化访谈。
经过翻译和修改的 PROFFIT 问卷表现出良好的心理语言学特性，包括高顺应性（仅为了澄清一个项目进行了修订）、高记忆检索、高决策过程和高反应过程。
PROFFIT 在新的社会环境中具有功能性和适应性。该工具可能有助于针对癌症人群中的经济困难进行干预和测量，这似乎是当前公共卫生的一个挑战。
即使在全民医疗保健系统中，由于自付费用的增加而导致的财务毒性也构成了一个重大问题。FT 现象值得在英国引起重视，因为它可能会对财务幸福感、生活质量、心理社会健康和治疗依从性产生负面影响。
