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一项关于低磁场磁刺激在认知障碍中的临床前和临床结果的系统评价和荟萃分析。

A systematic review and meta-analysis of the preclinical and clinical results of low-field magnetic stimulation in cognitive disorders.

机构信息

Faculty of Medicine and Dentistry, The University of Alberta, Edmonton, AB, T6G 2E1, Canada.

出版信息

Rev Neurosci. 2024 Apr 29;35(6):619-625. doi: 10.1515/revneuro-2024-0023. Print 2024 Aug 27.

Abstract

Cognitive disorders such as major depressive disorder and bipolar disorder severely compromise brain function and neuronal activity. Treatments to restore cognitive abilities can have severe side effects due to their intense and excitatory nature, in addition to the fact that they are expensive and invasive. Low-field magnetic stimulation (LFMS) is a novel non-invasive proposed treatment for cognitive disorders. It repairs issues in the brain by altering deep cortical areas with treatments of low-intensity magnetic stimulation. This paper aims to summarize the current literature on the effects and results of LFMS in cognitive disorders. We developed a search strategy to identify relevant studies utilizing LFMS and systematically searched eight scientific databases. Our review suggests that LFMS could be a viable and effective treatment for multiple cognitive disorders, especially major depressive disorder. Additionally, longer, more frequent, and more personalized LFMS treatments tend to be more efficacious.

摘要

认知障碍,如重度抑郁症和双相情感障碍,严重损害大脑功能和神经元活动。由于其强烈和兴奋的性质,以及治疗费用高和有侵入性,用于恢复认知能力的治疗可能会产生严重的副作用。低场磁刺激 (LFMS) 是一种新颖的非侵入性认知障碍治疗方法。它通过用低强度磁刺激治疗来改变深部皮质区域来修复大脑中的问题。本文旨在总结 LFMS 在认知障碍中的作用和效果的现有文献。我们制定了一项搜索策略,以利用 LFMS 识别相关研究,并系统地搜索了八个科学数据库。我们的综述表明,LFMS 可能是多种认知障碍的可行且有效的治疗方法,尤其是重度抑郁症。此外,更长、更频繁和更个性化的 LFMS 治疗往往更有效。

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本文引用的文献

1
Treatment resistance in psychiatry: state of the art and new directions.精神病学中的治疗抵抗:现状与新方向。
Mol Psychiatry. 2022 Jan;27(1):58-72. doi: 10.1038/s41380-021-01200-3. Epub 2021 Jul 13.
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Management of Treatment-Resistant Depression: Challenges and Strategies.难治性抑郁症的管理:挑战与策略
Neuropsychiatr Dis Treat. 2020 Jan 21;16:221-234. doi: 10.2147/NDT.S198774. eCollection 2020.
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Brain Neurosci Adv. 2019 May 30;2. doi: 10.1177/2398212818799271. Epub 2018 Oct 12.
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